Evidence map›Paper›PMID 41170449›Full record

ArticleFrontiers in oncology2025

The integrated analysis of SIRT family expression, prognostic value, and potential implications in childhood acute lymphoblastic leukemia.

Xusan Xu, Zhendong Wang, Xiaoxia Wang, Wensen Zhang, Zhengqiang Luo, Xiaomei Zheng, Ronghua Pan, Ying Fu, Yajun Wang, Guochun Huang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xusan Xu *Institute of Pediatric Hemato-oncology, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Zhendong Wang *Department of Pediatrics, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Xiaoxia Wang *Department of Neurology, Longjiang Hospital, Foshan, China.
Wensen ZhangDepartment of Pediatrics, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Zhengqiang LuoDepartment of Pediatrics, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Xiaomei ZhengDepartment of Pediatrics, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Ronghua PanDepartment of Pediatrics, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Ying FuInstitute of Pediatric Hemato-oncology, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Yajun WangInstitute of Pediatrics, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Guochun HuangDepartment of Pediatrics, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Riling ChenDepartment of Pediatrics, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.
Guoda MaInstitute of Pediatric Hemato-oncology, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute lymphoblastic leukemia (ALL) is a rapidly progressive hematological malignancy caused by the dysregulated proliferation and abnormal differentiation or differentiation block of lymphoid precursors. The sirtuin family, as a highly conserved class of protein deacetylases dependent on NAD Methods: In this study, we employed the Therapeutically Applicable Research to Generate Effective Treatments (TARGET), Genotype-Tissue Expression (GTEx), Encyclopedia of RNA Interactomes (ENCORI), Cancer Therapeutics Response Portal (CTRP), and STRING databases as well as R language to explore and visualize the role of the sirtuin family in childhood ALL. The receiver operating characteristic (ROC) curve was performed to investigate their diagnostic value, while the Kaplan-Meier survival curve and Cox regression analysis were utilized to test their prognostic value. Additionally, we conducted Pearson correlation analysis to explore the association between sirtuin family mRNA expression and DNA methylation. Results: Our results indicate that sirtuin family mRNA expression is dysregulated in pediatric ALL. The ROC curve revealed that SIRT1 and SIRT4 expression is highly sensitive and specific in diagnosing childhood ALL (AUC > 85.0%, Conclusions: SIRT1 represents a potential prognostic biomarker and therapeutic target in childhood B-ALL.

Indexed as

childhood acute lymphoblastic leukemiadrug sensitivityoverall survivalprognostic factorSIRT1

Identifiers

PMID41170449
PMCPMC12568422

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.