Evidence map›Paper›PMID 41170910›Full record

ArticleNanoscale2025

Extended osteoarthritis pain relief with neosaxitoxin using alginate-core polymeric microparticles.

Hengli Zhang, Helna M Baby, Shingo Ishihara, Chenzhen Zhang, Jun Li, Natalie S Adamczyk, Ezra M Cohen, Rachel E Miller, Ambika G Bajpayee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hengli ZhangDepartment of Bioengineering, Northeastern University, Boston, MA, USA. a.bajpayee@neu.edu.ORCID http://orcid.org/0009-0000-0918-8204
Helna M BabyDepartment of Bioengineering, Northeastern University, Boston, MA, USA. a.bajpayee@neu.edu.
Shingo IshiharaDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Chenzhen ZhangDepartment of Bioengineering, Northeastern University, Boston, MA, USA. a.bajpayee@neu.edu.
Jun LiDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Natalie S AdamczykDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Ezra M CohenDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Rachel E MillerDepartment of Internal Medicine, Division of Rheumatology, Rush University Medical Center, Chicago, IL, USA.
Ambika G BajpayeeDepartment of Bioengineering, Northeastern University, Boston, MA, USA. a.bajpayee@neu.edu.ORCID http://orcid.org/0000-0002-8458-7464

Funding

Tufts Clinical and Translational Science Institute (Pilot Supplement)UL1TR002544 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2018 to 2022
$50.2M
Neurobiology Core CP30AR079206 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI Anne-Marie Malfait · 2021 to 2026
$4.7M
The Role of Mechanosensation Pathways in Osteoarthritis Joint Damage and PainR01AR077019 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI Rachel Elizabeth Miller · 2021 to 2026
$2.7M
Intra-cartilage depot delivery of electrically-charged IL-1RA for targeting osteoarthritis-associated inflammation and catabolism in multiple joint tissuesR01AR075121 · NIAMS · NORTHEASTERN UNIVERSITY · PI BAJPAYEE, AMBIKA GOEL · 2020 to 2025
$2.5M
NCATS NIH HHS UL1 TR002544NIAMS NIH HHS P30 AR079206NIAMS NIH HHS R01 AR075121NIAMS NIH HHS R01 AR077019
6 · The paper itself

Abstract

Osteoarthritis (OA) is a leading cause of chronic pain, affecting millions worldwide. Conventional pharmacological treatments provide only short-term relief and pose risks with long-term use, highlighting the need for safer, sustained analgesic strategies. Voltage-gated sodium channels (Na

Indexed as

AlginatesOsteoarthritisSaxitoxinAnimalsDelayed-Action PreparationsMaleMiceNAV1.7 Voltage-Gated Sodium ChannelPolylactic Acid-Polyglycolic Acid CopolymerAlginatesDelayed-Action PreparationsNAV1.7 Voltage-Gated Sodium ChannelPolylactic Acid-Polyglycolic Acid CopolymerSaxitoxin

Identifiers

PMID41170910
PMCPMC12577283

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.