Construction of a 3D Bioprinted Microfluidic Platform to Study Breast Cancer Bone Metastasis and Tumor Microenvironmental Influences.

Ting-Wei Chang, Min-Wei Huang, Guo-Chung Dong, I-Chi Lee

Abstract read

In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

3D Bioprinted Breast Cancer-Stroma Model with Tailored Migration-Permissive Bioink Reveals Impact of Adipose-Derived Stromal Cells on Cancer Cell Migration and Invasion Dynamics.Advanced healthcare materials · 2026
Article
From Technological Innovation to Clinical Translation: Progress and Challenges in 3D Bioprinting for the Development of Breast Cancer Bone Metastasis Models.Advanced healthcare materials · 2026
Review
Developing Mammary Gland Models for Biomedical Applications.Research (Washington, D.C.) · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ting-Wei ChangDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 300044, Taiwan (R.O.C).

Min-Wei HuangDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 300044, Taiwan (R.O.C).

Guo-Chung DongInstitute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, No.35, Keyan Rd., Zhunan Town, Miaoli 35053, Taiwan (R.O.C).

I-Chi LeeDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 300044, Taiwan (R.O.C).ORCID 0000-0001-6527-0077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BrCa) frequently metastasizes to bone, severely compromising patient survival. Preventing metastatic spread is, therefore, a crucial therapeutic goal. Tumor matrix stiffness, growth factor gradients, and the bone microenvironment collectively influence cancer progression; however, existing

Indexed as

BioprintingBone NeoplasmsBreast NeoplasmsLab-On-A-Chip DevicesPrinting, Three-DimensionalTumor MicroenvironmentCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionFemaleHumansbone metastasisbreast cancer (BrCa) modelextravasationintravasationtumor microenvironment (TME)tumor spheroid laden bioprinting

Identifiers

PMID41171302

DOI10.1021/acsami.5c15529

PMCPMC12616590

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.