Evidence map›Paper›PMID 41171352›Full record

ArticleEuropean radiology2026

Brush sign on susceptibility-weighted imaging as a predictor of infarct growth in a single small subcortical infarction.

Shota Yoshimura, Susumu Yamaguchi, Hikaru Nakamura, Kosuke Hirayama, Kei Sato, Yoichi Morofuji, Takeshi Hiu, Yukishige Hayashi, Yoshiharu Tokunaga, Tsuyoshi Izumo and 1 more

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Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shota YoshimuraDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Susumu YamaguchiDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. ssmymgc@gmail.com.ORCID http://orcid.org/0000-0002-1029-4298
Hikaru NakamuraDepartment of Neurosurgery, Nagasaki Prefecture Shimabara Hospital, Nagasaki, Japan.
Kosuke HirayamaDepartment of Neurosurgery, Nagasaki Prefecture Shimabara Hospital, Nagasaki, Japan.
Kei SatoDepartment of Neurosurgery, Nagasaki Prefecture Shimabara Hospital, Nagasaki, Japan.
Yoichi MorofujiDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Takeshi HiuDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Yukishige HayashiDepartment of Neurosurgery, Nagasaki Prefecture Shimabara Hospital, Nagasaki, Japan.
Yoshiharu TokunagaDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Tsuyoshi IzumoDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Takayuki MatsuoDepartment of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesA single small subcortical infarction is sometimes strongly associated with infarct growth, ultimately leading to early neurological deterioration. We aimed to investigate whether a brush sign (BS) on susceptibility-weighted imaging (SWI) can predict infarct growth or progressive paralysis in a single small subcortical infarction. MATERIALS AND

methodsConsecutive patients with a single small subcortical infarction presenting within 24 h of onset were retrospectively evaluated. MRI, including SWI, was performed on admission and within 1 week of admission. Infarct growth was defined as an increase in infarct volume exceeding 0.5 cm

resultsOf the 67 patients (median age, 75 [62-83] years, 46 male) with a single small subcortical infarction, 13 (median age, 75 [59.5-84] years, 10 male) presented with a BS. The presence of a BS was associated with infarct growth; however, it was not an independent factor associated with progressive paralysis. On the other hand, infarct growth and age were independent factors associated with progressive paralysis.

conclusionA BS could indicate infarct growth in cases of a single small subcortical infarction. KEY POINTS: Question The usefulness of MRI in predicting infarct growth in a single small subcortical infarction has not been reported sufficiently. Findings The presence of a brush sign on susceptibility-weighted imaging was independently associated with infarct growth in a single small subcortical infarction. Clinical relevance A brush sign on susceptibility-weighted imaging has important implications, as early identification of patients at high risk of infarct growth can guide tailored treatment strategies and monitoring to improve patient outcomes.

Indexed as

Cerebral InfarctionMagnetic Resonance ImagingAgedAged, 80 and overDiffusion Magnetic Resonance ImagingDisease ProgressionFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesSingle small subcortical infarctionStrokeSusceptibility-weighted imaging

Identifiers

PMID41171352

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.