SynthesisNaunyn-Schmiedeberg's archives of pharmacology2026
Metabolomics in stress-related disorders: a systematic review and bioinformatics analysis.
Synthesis in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Biomarkers for complex post-traumatic stress disorder: translational and evolutionary perspectives.Frontiers in psychiatry · 2026Article
- A discovery plasma proteome signature in military personnel with chronic PTSD symptoms.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Stress-related disorders, including major depressive disorder (MDD), bipolar disorder (BD), and post-traumatic stress disorder (PTSD), share complex biological mechanisms and overlapping symptoms, posing challenges for diagnosis and treatment. This in silico study aimed to identify metabolomic patterns and explore dysfunctional metabolic pathways that are common and specific within a transdiagnostic psychiatric sample. A systematic review was conducted to identify metabolomic studies using mass spectrometry on blood samples from patients with MDD, BD, and PTSD. Study screening was performed using Rayyan, and metabolite codes were retrieved from the HMDB and ChEBI databases. Identified metabolites were classified using the R software, and metabolic pathway enrichment analysis was conducted in MetaboAnalyst. Thirteen eligible studies were identified, reporting 583 metabolites. Among these, four metabolites-arginine, inosine, 5-oxoproline (5-OP), and pyruvic acid-were consistently altered across disorders. Bioinformatics analysis revealed key metabolic pathways primarily related to amino acid, energy, carbohydrate, and lipid metabolism, suggesting shared biological mechanisms. These findings reinforce the transdiagnostic nature of metabolic dysfunction in psychiatric disorders and may contribute to the development of personalized therapeutic strategies and biomarker panels for improved diagnosis and treatment.
Indexed as
Identifiers
41171394What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.