Evidence map›Paper›PMID 41171502›Full record

ArticleFolia microbiologica2025

Antimicrobial activity of gentamicin-conjugated monometallic and bimetallic nanoparticles against multidrug-resistant Klebsiella pneumoniae strains.

Samira Zakeer, Mariam E Amin, Gharieb S El-Sayyad, Rasha Mohammad Fathy, Ahmed I El-Batal, Shymaa Enany

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Article in Folia microbiologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samira Zakeer *Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Mariam E Amin *Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Gharieb S El-SayyadMedical Laboratory Technology Department, Faculty of Applied Health Sciences Technology, Badr University in Cairo (BUC), Cairo, Egypt. Gharieb.El-Saied@buc.edu.eg.ORCID http://orcid.org/0000-0001-5410-7936
Rasha Mohammad FathyDrug Microbiology Lab., Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.ORCID http://orcid.org/0000-0002-2902-2882
Ahmed I El-BatalDrug Microbiology Lab., Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.ORCID http://orcid.org/0000-0001-5227-9531
Shymaa EnanyDepartment of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. shymaa21@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug-resistant Klebsiella pneumoniae (MDR-KP) poses a significant clinical challenge due to limited therapeutic options and high mortality. This study investigated the antimicrobial efficacy of gamma-irradiation-synthesized gentamicin-conjugated silver nanoparticles (Gent-Ag NPs), copper oxide nanoparticles (CuO NPs), and bimetallic Ag-CuO NPs against three MDR-KP isolates in comparison with the gamma-irradiated gentamicin alone. Gent-Ag, Gent-CuO, and bimetallic Gent-Ag-CuO NPs were synthesized via gamma-radiation-induced reduction and characterized by different analytical methods to confirm their shape, size, surface morphology, particle size distribution, and crystallinity using HRTEM, SEM, DLS, and XRD, respectively. Comparative analysis demonstrated that Gent-Ag NPs exhibited superior antimicrobial activity, while Gent-CuO NPs showed diminished efficacy. SEM imaging analysis showed that Gent-Ag-CuO NPs effectively damaged and weakened the bacterial surfaces. It should be noted that the complete lys of K. pneumoniae cells is depicted by the white holes seen inside the bacteria. These findings suggest potential therapeutic applications of Ag-based NPs against MDR-KP, warranting further validation with larger sample sizes.

Indexed as

Bimetallic nanomaterialsCopper oxide nanoparticlesKlebsiella pneumoniaeMultidrug resistanceSilver nanoparticles

Identifiers

PMID41171502

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.