Evidence map›Paper›PMID 41173007›Full record

ArticleStem cell reports2025

Circadian regulation of insulin secretion in transplanted human stem cell-derived pancreatic β-cells.

Satish K Sen, Zenith Khashim, Sharath Shivakumar Belame, Shaimaa Hassoun, Tiana Salomon, Sean Lewis-Brinkman, Matthew R Brown, Luhui Zhang, Quinn P Peterson, Aleksey V Matveyenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Satish K SenDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Zenith KhashimDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Sharath Shivakumar BelameDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Shaimaa HassounDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Tiana SalomonDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Sean Lewis-BrinkmanDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Matthew R BrownDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Luhui ZhangDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA.
Quinn P PetersonDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA; Department of Medicine, Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Mayo Clinic School of Medicine, Rochester, MN, USA; Center for Regenerative Biotherapeutics, Mayo Clinic, Rochester, MN, USA. Electronic address: peterson.quinn@mayo.edu.
Aleksey V MatveyenkoDepartment of Physiology and Biomedical Engineering, Mayo Clinic School of Medicine, Rochester, MN, USA; Department of Medicine, Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Mayo Clinic School of Medicine, Rochester, MN, USA; Center for Regenerative Biotherapeutics, Mayo Clinic, Rochester, MN, USA. Electronic address: matveyenko.aleksey@mayo.edu.

Funding

Role of Circadian Misalignment in Beta-cell Failure in Type 2 DiabetesR01DK098468 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ALEKSEY V MATVEYENKO · 2013 to 2026
$5.8M
NIDDK NIH HHS R01 DK098468
6 · The paper itself

Abstract

Cell replacement strategies utilizing stem cell-derived pancreatic β-cells (SCβ-cells) hold therapeutic potential for patients with diabetes. However, little is known about how endogenous (host) and exogenous (transplant) circadian systems interact to influence the engraftment and function of SCβ-cells. We report that differentiation of SCβ-cells in vitro is associated with the induction of key circadian clock genes known to regulate insulin secretion. Upon transplantation into severe combined immunodeficiency (SCID)-beige mice, SCβ-cells exhibit circadian rhythms in glucose-stimulated insulin secretion optimized to the host's active circadian phase. Furthermore, disrupting the host's circadian rhythms abolishes circadian regulation and the overall functional capacity of transplanted SCβ-cells. These observations suggest that the host's circadian system entrains SCβ-cell function to optimize the circadian control of insulin secretion.

Indexed as

Circadian RhythmInsulinInsulin-Secreting CellsStem CellsStem Cell TransplantationAnimalsCell DifferentiationCircadian ClocksGlucoseHumansInsulin SecretionMiceMice, SCIDGlucoseInsulin

Identifiers

PMID41173007
PMCPMC12790728

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.