Evidence map›Paper›PMID 41173008›Full record

ArticleStem cell reports2025

Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells.

Luca Caputo, Cedomir Stamenkovic, Matthew T Tierney, Alessandra Cecchini, Monica Nicolau, Gabriele Guarnaccia, Jesus R Barajas, Maria Sofia Falzarano, Rhonda Bassel-Duby, Alessandra Ferlini and 3 more

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Article in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Luca CaputoCardiovascular and Muscular Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: lcaputo@sbpdiscovery.org.
Cedomir StamenkovicCardiovascular and Muscular Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Matthew T TierneyCardiovascular and Muscular Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Alessandra CecchiniCardiovascular and Muscular Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Monica NicolauCardiovascular and Muscular Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Gabriele GuarnacciaCardiovascular and Muscular Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA; Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Jesus R BarajasCardiovascular and Muscular Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Maria Sofia FalzaranoUOL Medical Genetics, University of Ferrara, 44121 Ferrara, Italy.
Rhonda Bassel-DubyDepartment of Molecular Biology, Hamon Center for Regenerative Science and Medicine, Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Alessandra FerliniUOL Medical Genetics, University of Ferrara, 44121 Ferrara, Italy.
Eric N OlsonDepartment of Molecular Biology, Hamon Center for Regenerative Science and Medicine, Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Pier Lorenzo PuriCardiovascular and Muscular Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Alessandra SaccoCardiovascular and Muscular Diseases Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: asacco@sbpdiscovery.org.

Funding

Pathogenic Alterations of the 3D Epigenetic Landscape in Dystrophin-Deficient Skeletal Muscles and Reversal by Dystrophin Re-ExpressionR01AR056712 · NIAMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Pier Lorenzo Puri · 2009 to 2026
$7.3M
NIAMS NIH HHS R01 AR056712
6 · The paper itself

Abstract

Generation of in vitro human induced pluripotent cell (hiPSC)-derived skeletal muscle progenitor cells (SMPCs) holds great promise for regenerative medicine for skeletal muscle wasting diseases, for example Duchenne muscular dystrophy (DMD). While multiple approaches have been described to obtain SMPCs in vitro, hiPSC-derived SMPCs generated using transgene-free protocols are usually obtained in a low amount and resemble a more embryonal/fetal stage of differentiation. Here, we demonstrate that modulation of the JAK2/STAT3 signaling pathway during an in vitro skeletal muscle differentiation protocol increases the yield of PAX7

Indexed as

Induced Pluripotent Stem CellsJanus Kinase 2Muscle DevelopmentSignal TransductionSTAT3 Transcription FactorAnimalsCell DifferentiationCell ProliferationCells, CulturedHumansMiceMuscle Fibers, SkeletalMuscular Dystrophy, DuchenneJAK2 protein, humanJanus Kinase 2STAT3 protein, humanSTAT3 Transcription FactorDuchenne muscular dystrophyhiPSCmyotubesskeletal muscle progenitor cells, myogenic maturation, skeletal muscle regeneration, cell therapySTAT3 pathway

Identifiers

PMID41173008
PMCPMC12790747

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.