Evidence mapPaperPMID 41173049Full record

SynthesisArquivos de neuro-psiquiatria2025

Prognostic biomarkers in ischemic stroke treated with mechanical thrombectomy: a systematic review.

Rodrigo Fellipe Rodrigues, Raquel Cristina Trovo Hidalgo, Savio Batista, Júlia Belone Lopes, Gabriel Paulo Mantovani, Pedro Henrique Matos Oliveira, André Nishizima, Anderson Silva Corin, Lucas Macedo, Mariana Letícia de Bastos Maximiano and 3 more

Abstract readSystematic Review
In one paragraph

Synthesis in Arquivos de neuro-psiquiatria, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rodrigo Fellipe RodriguesUniversidade Federal de São Paulo, Programa de Pós-Graduação em Biologia Estrutural e Funcional, São Paulo, SP, Brazil.ORCID 0000-0003-1465-6265
Raquel Cristina Trovo HidalgoFaculdade de Medicina de São José do Rio Preto, Departamento de Neurorradiologia Intervencionista, São José do Rio Preto, SP, Brazil.ORCID 0000-0002-3749-9218
Savio BatistaEmory University, Department of Neurology, Atlanta, GA, USA.ORCID 0000-0002-6861-0505
Júlia Belone LopesFaculdade de Medicina de São José do Rio Preto, Departamento de Oncologia Clínica, São José do Rio Preto, SP, Brazil.ORCID 0009-0008-3209-5733
Gabriel Paulo MantovaniHospital de Clínicas de Porto Alegre, Departamento de Neurologia, Porto Alegre, RS, Brazil.ORCID 0000-0003-3187-0220
Pedro Henrique Matos OliveiraEscola Bahiana de Medicina e Saúde Pública, Departamento de Medicina, Salvador, BA, Brazil.ORCID 0009-0004-2839-7828
André NishizimaEscola Bahiana de Medicina e Saúde Pública, Departamento de Medicina, Salvador, BA, Brazil.ORCID 0009-0008-9835-9850
Anderson Silva CorinUniversidade Federal de Pelotas, Departamento de Medicina, Pelotas, RS, Brazil.ORCID 0009-0004-1148-7085
Lucas MacedoUniversidade de Brasília, Departamento de Medicina, Brasília, DF, Brazil.ORCID 0009-0006-8161-6430
Mariana Letícia de Bastos MaximianoUniversidade Federal Fluminense, Departamento de Medicina, Rio de Janeiro, RJ, Brazil.ORCID 0009-0005-8359-6763
Pedro Lucas Machado MagalhãesInstituto de Educação Médica, Departamento de Medicina, Angra dos Reis, RJ, Brazil.ORCID 0009-0004-1840-2953
Julia Camargo RicciUniversidade Estadual Paulista "Júlio de Mesquita Filho", Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Preto, SP, Brazil.ORCID 0009-0003-4847-2728
Sonia Maria OlianiUniversidade Federal de São Paulo, Programa de Pós-Graduação em Biologia Estrutural e Funcional, São Paulo, SP, Brazil.ORCID 0000-0003-0918-2130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical thrombectomy (MT) is a key therapy for acute ischemic stroke (AIS), improving survival and functional outcomes. However, the variability in results highlights the need for predictive markers to refine patient selection. Biomarkers reflecting inflammation and metabolic stress are gaining recognition for their role in AIS and MT outcomes.To systematically review and synthesize the evidence on biomarkers associated with clinical outcomes in AIS patients undergoing MT. Specific aims include evaluating their relationship with functional recovery (mRS), mortality, infarct volume, hemorrhagic transformation, and complications such as malignant brain edema (MBE) and delayed cerebral ischemia (DCI).A systematic review of the literature was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to identify studies evaluating biomarkers in MT. The PubMed and Embase databases were searched using the following terms: (

Indexed as

Ischemic StrokeThrombectomyBiomarkersHumansPrognosisTreatment OutcomeBiomarkers

Identifiers

PMID41173049
PMCPMC12578577

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.