ArticleStem cells translational medicine2025
Lithium chloride-treated human umbilical cord mesenchymal stem cells-derived exsomes promote hair growth by regulating miR-146a-5p-wnt pathway.
Article in Stem cells translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
5 authors.
Funding
Abstract
The regulation of the hair cycle is orchestrated by a complex network of signaling pathways, and substantial evidence from extensive research indicates that exosomal miRNAs may play a pivotal role in this process. In this study, we present compelling evidence that exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSCs), pretreated with the Wnt pathway agonist lithium chloride (LiCl), significantly enhance hair regeneration. High-throughput sequencing was utilized to identify differentially expressed miRNAs in exosomes from both LiCl-pre-treated and untreated groups, thereby elucidating potential mechanisms underlying this phenomenon. Specifically, miR-146a-5p was found to activate the Wnt signaling pathway, thereby promoting the proliferation and migration of primary dermal papilla cells in mice. The downstream target genes of miR-146a-5p, including SFRP1, SMAD2, SMAD4, and EGFR, were predicted using bioinformatics tools and subsequently validated through experimental validation. An animal model overexpressing miR-146a-5p was constructed, demonstrating that miR-146a-5p targets SFRP1 to promote hair regeneration in mice via activation of the Wnt signaling pathway.
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Registered trials
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