Evidence map›Paper›PMID 41173886›Full record

ArticleNature communications2025

Neutrophil elastase-activatable ratiometric photoacoustic nanoprobes for imaging atherosclerotic plaque vulnerability.

Hui Cao, Xin Meng, Yuan Ma, Zhe Li, Xinyu Xu, Jiaqi Fu, Qingpeng Zhang, Hanlin Wei, Peng Liang, Dingyou Lu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hui CaoState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Xin MengState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Yuan MaState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Zhe LiState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Xinyu XuState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.ORCID http://orcid.org/0000-0003-4348-9988
Jiaqi FuState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Qingpeng ZhangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Hanlin WeiState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Peng LiangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Dingyou LuState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Jinyu LiState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Baoli YinState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Shuangyan HuanState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Xiao-Bing ZhangState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China. xbzhang@hnu.edu.cn.ORCID http://orcid.org/0000-0002-4010-0028
Guosheng SongState Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China. songgs@hnu.edu.cn.ORCID http://orcid.org/0000-0001-5628-6245

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis is a leading cause of cardiovascular diseases worldwide. Neutrophil elastase, a key protease secreted by neutrophils, contributes significantly to atherosclerosis by degrading the extracellular matrix and destabilizing the fibrous cap of plaques. However, current detection methods for neutrophil elastase lack the ability to monitor its dynamic changes within plaques in a non-invasive and real-time manner. To overcome this limitation, we develop a neutrophil elastase-activated semiconductor polymer nanoprobe with high selectivity, sensitivity, and resistance to interference. We successfully establish a calibration curve correlating the in vivo photoacoustic signal ratio with neutrophil elastase concentration, enabling quantification of intraplaque neutrophil elastase levels. Importantly, we introduce a vulnerability index to assess plaque instability, allowing the nanoprobe to predict the adverse effects of inflammatory responses on the risk of plaque rupture in ApoE

Indexed as

AtherosclerosisLeukocyte ElastasePhotoacoustic TechniquesPlaque, AtheroscleroticAnimalsApolipoproteins EHumansMaleMiceMice, Inbred C57BLMice, Knockout, ApoENeutrophilsApolipoproteins ELeukocyte Elastase

Identifiers

PMID41173886
PMCPMC12579233

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.