Evidence map›Paper›PMID 41174264›Full record

SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026

Probiotic Supplementation and Bone Health Parameters in Adults: A Systematic Review and Meta-Analysis.

Khemayanto Hidayat, Yan Zhu, René Rizzoli, Hong Wei, Bi-Min Shi, Li-Qiang Qin

Erratum issuedAbstract readSystematic ReviewMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Khemayanto Hidayat *Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, China. khemayanto@suda.edu.cn.ORCID http://orcid.org/0000-0002-4095-6969
Yan Zhu *Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
René RizzoliDivision of Bone Diseases, Department of Internal Medicine, Faculty of Medicine, Geneva University Hospitals, 1211, Geneva, Switzerland.
Hong WeiDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, China.
Bi-Min ShiDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. shibimin@163.com.
Li-Qiang QinDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, China. qinliqiang@suda.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGut microbiota has been implicated in bone health. However, the extent of the skeletal benefits of probiotic supplementation in humans remains unclear. A systematic review and meta-analysis was performed to appraise the efficacy of probiotic supplementation in improving bone health through a comprehensive qualitative and quantitative synthesis of the available randomized controlled trials.

methodsThe PubMed, Web of Science, and China National Knowledge Infrastructure databases were searched for RCTs reporting the effects of probiotic supplementation on bone mineral density (BMD), C-terminal telopeptide of type 1 collagen (CTX), or procollagen type 1 N-propeptide (P1NP). A random-effects model was used to generate the pooled weighted mean differences and 95% confidence intervals.

resultsProbiotic supplementation significantly increased lumbar spine aBMD (areal BMD) (+ 0.010; n = 16) and hip aBMD (+ 0.022 g/cm

conclusionBased on the evidence from the currently available RCTs, probiotic supplementation appears to lead to modest but statistically significant improvement in lumbar spine BMD and, to a lesser extent, hip BMD in postmenopausal women.

Indexed as

Bone DensityProbioticsCollagen Type IDietary SupplementsFemur NeckGastrointestinal MicrobiomeHip JointHumansLumbar VertebraePeptide FragmentsProcollagenRandomized Controlled Trials as TopicCollagen Type IPeptide FragmentsProcollagenBone mineral densityGut-bone axisGut microbiotaOsteporosisProbiotics

Identifiers

PMID41174264

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.