Evidence map›Paper›PMID 41174334›Full record

ReviewNatural products and bioprospecting2025

Advancement in nanocarrier-mediated delivery of herbal bioactives: from bench to beside.

Fatemeh Najafi, Negar Farrokhzad, Amirhossein Ghaemi, Dorsa Azizi Khezri, Mohammadali Hajiabbas, Amirhossein Khanizadeh, Nasim Kaveh Farsani, Mahsa Khoramipour, Niloofar Fatemipayam, Elham Seyyedi Zadeh and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Natural products and bioprospecting, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Fatemeh Najafi *Department of Chemical Engineering, Pennsylvania State University, University Park, PA, 16802-1503, USA.
Negar Farrokhzad *Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Amirhossein GhaemiDepartment of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Dorsa Azizi KhezriSchool of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
Mohammadali HajiabbasDepartment of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran.
Amirhossein KhanizadehDepartment of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Nasim Kaveh FarsaniDepartment of Chemical Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran.
Mahsa KhoramipourDepartment of Biology, Faculty of Sciences, Arak University, Arak, Iran.
Niloofar FatemipayamChemical Engineering Department, Oklahoma State University, Stillwater, OK, USA.
Elham Seyyedi ZadehDepartment of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Arash GoodarziDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, 74615-168, Iran.
Behnoosh KhodadadiDepartment of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Tehran, Iran.
Fatemeh MoradbeygiDepartment of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, 71348-14336, Iran.
Ahmad Reza FarmaniDepartment of Tissue Engineering, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, 74615-168, Iran. ahmadrezafarmani66@gmail.com.ORCID http://orcid.org/0000-0003-1149-3843
Mohammad Tavakkoli YarakiSchool of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW, 2109, Australia. mty206@yahoo.com.
Martin Federico DesimoneUniversidade Federal Do Rio Grande (FURG), Instituto de Ciências Biológicas (ICB), Programa de Pós-Graduação Em Ciências Fisiológicas (PPGCF), Rio Grande, RS, Brazil. desimone@ffyb.uba.ar.

Funding

Fasa University of Medical Sciences 403289
6 · The paper itself

Abstract

The resurgence of interest in traditional herbal remedies stems from an increasing appreciation for their complex phytochemical profiles and potential for synergistic therapeutic effects. However, the therapeutic potential of plant extracts is often limited by poor absorption and potential toxicity related to conventional delivery methods. This review explores the application of nanocarrier-mediated delivery systems, such as nanoparticles (NPs), liposomes, and nanoemulsions, to address these challenges. These biocompatible carriers offer enhanced stability and targeted delivery of herbal compounds, improving their efficacy and reducing unwanted side effects. By enabling precise distribution, nanotechnology optimizes the potency of herbal medicine across diverse applications, including regenerative medicine, wound healing, anticancer, and infection treatment. This review provides a systematic description of successful applications of nano-delivery technologies, nanoparticles, liposomes, nanoemulsions, and hybrid carriers, for the targeted delivery of some well-characterized herbal bioactives (curcumin, allicin, berberine, resveratrol etc.) and the enhanced therapeutic performance of herbal bioactives across a variety of preclinical models.

Indexed as

BioavailabilityHerbal compoundsNano-delivery systemsTissue engineeringWound healing

Identifiers

PMID41174334
PMCPMC12579071

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.