Evidence map›Paper›PMID 41174540›Full record

ArticleBMC neurology2025

Characteristics of brain glucose metabolism in Parkinson's disease patients with freezing of gait: a study based on

Zhuang Zhu, Yao Geng, Xixi Wang, Jiaxin Shi, Hualin Wang, Linghui Liu, Shengrong Li, Caiting Gan, Yongsheng Yuan, Qi Zhu and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhuang Zhu *Department of Neurology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Yao Geng *Department of Neurology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Xixi Wang *Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Jiaxin ShiDepartment of Neurology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Hualin WangDepartment of Neurology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Linghui LiuCollege of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Shengrong LiCollege of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Caiting GanDepartment of Neurology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Yongsheng YuanDepartment of Neurology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Qi ZhuCollege of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, China. zhuqinuaa@163.com.
Kezhong ZhangDepartment of Neurology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. kezhong_zhang1969@126.com.

Funding

the National Natural Science Foundation of China 82271273
6 · The paper itself

Abstract

objectiveFreezing of gait (FOG) is a common gait disorder in the advanced stages of Parkinson's disease (PD), closely associated with impaired balance and executive function. This study aimed to investigate specific changes in brain glucose metabolism in FOG patients using

methodsEighteen PD patients with FOG(PD-FOG), 11 patients without FOG (PD-NFOG) and 17 healthy controls (HC) were recruited. All participants underwent

resultsPET imaging analysis showed that the differences between the PD-FOG group and the PD-NFOG group were mainly located in the frontal lobe, parietal lobe and cingulate gyrus. The 3D CNN achieved diagnostic accuracies of 90.09% for distinguishing PD and 95.40% for FOG, surpassing other machine learning models. The 3D CNN achieved the smallest mean squared error (MSE), amounting to 48.01, in the prediction of Freezing of Gait Questionnaire (FOG-Q) scores.

conclusionSpecific glucose metabolism patterns in PD-FOG mainly covered the frontoparietal network (FPN). The integration of

Indexed as

BrainDeep LearningGait Disorders, NeurologicGlucoseParkinson DiseasePositron-Emission TomographyAgedFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedNeural Networks, ComputerFluorodeoxyglucose F18Glucose18F-FDG PET3D convolutional neural networkBrain glucose metabolismFreezing of gaitParkinson’s disease

Identifiers

PMID41174540
PMCPMC12577301

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.