ReviewStem cell research & therapy2025
Functionalized mesenchymal stem cells for enhanced bone regeneration: advances and challenges.
Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Treatment of pulmonary fibrosis: From disease mechanisms to future novel therapies (Review).International journal of molecular medicine · 2026Review
- Managing Bone Infections Beyond Systemic Antibiotics: A Scoping Review.Pathogens (Basel, Switzerland) · 2026Review
- G protein-coupled receptor signaling in osteogenic bone mesenchymal stem/stromal cells.Frontiers in cell and developmental biology · 2026Review
- A Nanomedicine Strategy: Spatiotemporally Programmed Delivery of Engineered Exosomes via Smart Scaffolds for Craniofacial Bone Regeneration.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Bone fracture continues to pose a significant clinical challenge in regenerative medicine due to limited repair capacity and inadequate therapeutic options. Among the various therapeutic strategies, mesenchymal stem cells have shown strong potential due to their ability to promote bone formation, modulate inflammation, and migrate to injury sites. However, clinical outcomes have been limited by issues like low survival rates, poor integration, and non-specific distribution after transplantation. Functionalized mesenchymal cells enhanced through genetic, chemical, or material-based modifications have emerged as an advanced strategy to overcome these limitations and significantly improve bone regeneration. This review explores recent developments in the functionalization of stem cells to increase their bone-forming potential. It covers techniques of gene modification, preconditioning, nanoparticle integration, and scaffold-based delivery. The role of these engineered cells is in activating key pathways involved in bone repair, including bone morphogenetic proteins and Wnt signaling. Furthermore, the study highlights current delivery platforms, including injectable gels, printed scaffolds, and bioactive coatings that support targeted, sustained cell activity. Despite encouraging preclinical outcomes, unresolved challenges in manufacturing, immune compatibility, and regulatory pathways persist, prompting the exploration of emerging solutions like precision-engineered implants and artificial intelligence-driven design to guide the future of advanced bone regeneration therapies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.