Evidence map›Paper›PMID 41174864›Full record

ArticleJournal of diabetes investigation2025

Using automated insulin delivery to address the clinical challenges of glycemic management in people with type 1 diabetes and kidney failure on maintenance hemodialysis.

Panagiotis Pavlou, Monika Reddy, Parizad Avari, Lalantha Leelarathna, Rachael Tan, Tahseen A Chowdhury, Rebecca Hyslop, Sufyan Hussain, Thomas Johnston, Janaka Karalliedde

Abstract read
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In one paragraph

Article in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Panagiotis PavlouKing's College London, London, UK.ORCID https://orcid.org/0000-0002-4106-4911
Monika ReddyImperial College Healthcare NHS Trust, London, UK.
Parizad AvariImperial College Healthcare NHS Trust, London, UK.
Lalantha LeelarathnaImperial College Healthcare NHS Trust, London, UK.
Rachael TanKing's College London, London, UK.
Tahseen A ChowdhuryBarts Health NHS Trust, London, UK.
Rebecca HyslopGuy's and St Thomas' NHS Foundation Trust, London, UK.
Sufyan HussainKing's College London, London, UK.
Thomas JohnstonGuy's and St Thomas' NHS Foundation Trust, London, UK.
Janaka KarallieddeKing's College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes management in end-stage kidney disease (ESKD) is complicated by altered insulin pharmacokinetics and glucose metabolism, particularly in the context of hemodialysis (HD). Automated insulin delivery (AID) systems offer dynamic insulin adjustment and may help address these challenges. We present real-world data from nine individuals (five females) with type 1 diabetes and ESKD on HD, median age 38 years (range 33-50). Over a median follow-up of 7 months (range 1.5-25), AID use led to significant improvements in glucose time in range (3.9-10 mmol/l) which increased from 39.7% to 59.8% (P = 0.001), glucose variability decreased from 39.8% to 33.8% (P = 0.01), and HbA1c improved from 78.6 to 56.1 mmol/mol (P = 0.003). Time below range fell from 4.0% to 1.4%, but this was not significant (P = 0.1). AID was well tolerated and implemented with multidisciplinary support. Our findings highlight the potential of AID to improve glycemic control in this high-risk population and the need for further studies in this area.

Indexed as

Diabetes Mellitus, Type 1Glycemic ControlHypoglycemic AgentsInsulinInsulin Infusion SystemsKidney Failure, ChronicRenal DialysisAdultBlood GlucoseFemaleFollow-Up StudiesGlycated HemoglobinHumansMaleMiddle AgedBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulinAutomated insulin deliveryDiabetic nephropathyType 1 diabetes mellitus

Identifiers

PMID41174864
PMCPMC12578668

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.