ReviewJournal of endocrinological investigation2026
Role of Notch signaling in corticalization.
Review in Journal of endocrinological investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Bone is a complex structure formed by cancellous and cortical bone compartments. Whereas cancellous bone remodeling has been studied extensively, less is known about mechanisms that lead to cortical bone formation and homeostasis. Corticalization is a poorly understood process, when newly formed trabeculae coalesce to consolidate as cortical bone in early life, but with an impact on skeletal integrity that is sustained throughout life. Failure to form cortical bone results in pronounced skeletal fragility, although the process is poorly understood. Mouse models of Sp7, Itgb3, Socs3 and Clcn7 inactivation exhibit impaired corticalization and cancellous bone osteopetrosis. The relationship between the two events has not been established. Notch receptors (1 through 4) are critical determinants of cell differentiation and function in the skeleton. NOTCH3 is structurally distinct and has a well-defined pattern of cellular expression, in smooth muscle vascular cells and osteocytes, conferring this Notch receptor a unique role in physiology. Mouse models expressing the biological active NOTCH3 intracellular domain (N3ICD) in Bglap
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.