ReviewActa physiologica (Oxford, England)2025
Mechanisms That Prevent Vascular Leakage During Leukocyte Extravasation.
Review in Acta physiologica (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Targeting CD4⁺ T cell infiltration: mechanisms and therapeutic insights into CD4⁺ T cell transmigration across the blood-brain barrier in acute ischemic stroke.Fluids and barriers of the CNS · 2026Review
- Mechanisms That Prevent Vascular Leakage During Leukocyte Extravasation.Acta physiologica (Oxford, England) · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundInflammation is the response of the immune system against harmful stimuli in tissues. Leukocyte extravasation or TransEndothelial Migration (TEM) is a crucial step during inflammation, in which leukocytes migrate over the endothelial barrier toward the damaged tissue.
objectiveHistorically, it was believed that leukocyte TEM directly causes excessive vascular leakage, resulting in tissue edema. However, it is now clear that leukocyte TEM and vascular leakage are uncoupled events with different spatiotemporal regulation. Moreover, several mechanisms have been identified that prevent vascular leakage during leukocyte TEM.
conclusionHere we summarize the different mechanisms that are responsible for limiting the leakage during the transmigration event and explore their clinical relevance in developing targeted therapeutics for controlling vascular leakage in inflammatory diseases.
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