Evidence map›Paper›PMID 41176776›Full record

ArticleEpigenetics2025

Expression profiles of histone H4K20 methylation and its associated enzymes in mouse cardiac disease and human heart failure.

Samuel Hickenlooper, Cameron Brady, Ryan Bia, Joseph R Visker, Li Wang, Steven Valdez, Clint Gwynn, Maya N Roland, Christos P Kyriakopoulos, Konstantinos Sideris and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. ThebioRxiv : the preprint server for biology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Samuel HickenlooperNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.
Cameron BradyNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.
Ryan BiaNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.
Joseph R ViskerNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.
Li WangNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.
Steven ValdezNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.
Clint GwynnNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.
Maya N RolandNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.
Christos P KyriakopoulosNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.
Konstantinos SiderisNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.
Stavros G DrakosNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.
Marta W SzulikNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.ORCID 0000-0001-5412-8219
Sarah FranklinNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake, UT, USA.

Funding

TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
The methyltransferase Smyd1 regulates cardiac physiologyR01HL161045 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Sarah Franklin · 2022 to 2026
$1.9M
Regulation of cardiac hypertrophy and failure by the histone methyltransferase Smyd1R01HL130424 · NHLBI · UNIVERSITY OF UTAH · PI FRANKLIN, SARAH · 2016 to 2019
$1.5M
Metabolite Transport Modulation to Mitigate Ischemic-Reperfusion InjuryK99HL175185 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Joseph R. Visker · 2025 to 2026
$367k
NHLBI NIH HHS K99 HL175185NHLBI NIH HHS R01 HL130424NHLBI NIH HHS R01 HL161045NHLBI NIH HHS T32 HL007576
6 · The paper itself

Abstract

Histone H4K20 methylation is critical in regulating the cell cycle, DNA damage response, and gene repression in proliferating cells. However, its role in the heart remains poorly understood. Our previous work revealed that histone H4K20 tri-methylation is elevated in acute cell models of cardiomyocyte hypertrophy but is reduced in mouse models of cardiac hypertrophy and ischemia. Although these findings highlight the dynamic nature of this modification and its significance in regulating gene expression, the data on enzymes regulating H4K20 methylation is sparse. To build upon this work and investigate H4K20 di-methylation and the enzymes modulating this site in cardiac pathology, we quantified histone H4K20 di-methylation and 12 methyltransferases and demethylases across one cell model, two mouse models of cardiac dysfunction, and cardiac tissue from heart failure patients. While we observed no global changes in H4K20 di-methylation, we detected alterations in methyltransferases

Indexed as

Heart FailureHistonesAnimalsDNA-Binding ProteinsHistone DemethylasesHistone-Lysine N-MethyltransferaseHumansMaleMethylationMiceMice, Inbred C57BLDNA-Binding ProteinsHistone DemethylasesHistone-Lysine N-MethyltransferaseHistonesKMT5C protein, humancardiacdemethylasediseaseEpigeneticshearthistone H4K20 methylationischemiamethyltransferase

Identifiers

PMID41176776
PMCPMC12582106

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.