Evidence map›Paper›PMID 41177430›Full record

ReviewJournal of advanced research2026

Tetrahedral framework nucleic acids: Nanokeys unlocking a new era of precision biomedicine.

Zhenhong He, Yi Liu, Yihuang Chen, Yuanqun Zhang, Yuyao Zhang, Zhihong Chen, Dingsu Bao, Weihu Yang, Huan Liu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhenhong HeDepartment of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China; College of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: hzhhzhhzh7@163.com.
Yi LiuClinical Medicine College, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: 18981636587@163.com.
Yihuang ChenPutian University, Putian, Fujian 351106, China. Electronic address: 18876343873@163.com.
Yuanqun ZhangPutian University, Putian, Fujian 351106, China. Electronic address: 15059617484@163.com.
Yuyao ZhangDepartment of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China; College of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: 937858379@qq.com.
Zhihong ChenPutian University, Putian, Fujian 351106, China. Electronic address: 15159819075@163.com.
Dingsu BaoDepartment of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China; College of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: 332639420@qq.com.
Weihu YangKey Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China. Electronic address: yangweihu@cqu.edu.cn.
Huan LiuDepartment of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China; Orthopaedic Research Center and Key Laboratory, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: 20016040@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tetrahedral framework nucleic acids (tFNAs), a crucial component of DNA nanotechnology, have emerged as versatile tools in biomedical research, largely owing to their distinctive structural features and multifaceted capabilities. Recent studies have highlighted the ability of tFNAs to specifically target biological pathways, facilitate cellular uptake, and enhance therapeutic efficacy. tFNAs also show considerable potential in addressing challenges such as drug resistance and poor bioavailability. However, several challenges, including limited in vivo stability, low drug-loading capacity, and potential long-term toxicity, need to be addressed for successful clinical translation. This review comprehensively explores the latest advancements in tFNAs, focusing particularly on their applications and mechanisms in treating a wide array of diseases. From bone diseases to ophthalmic disorders, tFNAs not only promote bone regeneration but also enhance therapeutic efficacy through targeted drug delivery. They also play a role in combating infectious diseases, skin and soft tissue repair, neurological and mental disorders, hepatorenal diseases, and cancer. In addition, tFNAs have demonstrated significant potential in regenerative medicine, immunomodulation, and gene delivery. This work highlights the future potential of DNA nanotechnology in precision medicine, paving the way for next-generation therapeutic strategies.

Indexed as

NanotechnologyNucleic AcidsPrecision MedicineAnimalsDNA NanostructuresDrug Delivery SystemsHumansNanomedicineRegenerative MedicineNucleic AcidsDrug deliveryNanomedicinePrecision medicineTetrahedral framework nucleic acidsTissue repair

Identifiers

PMID41177430
PMCPMC13316439

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.