SynthesisMini reviews in medicinal chemistry2025
New Insights from Toxinology in Mammalian Reproduction: A Systematic Review.
Synthesis in Mini reviews in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAssisted reproductive techniques still have limitations regarding embryonic development and the achievement of clinical pregnancy. Animal venoms represent a biological library with the potential to trigger relevant cellular mechanisms. This study aimed to evaluate, through a literature review and computational screening, the activity of natural venoms and their derivatives on germ cells. MATERIALS AND
methodsA literature review was conducted in PubMed, Embase, Scopus, and Web of Science databases. INCLUSION CRITERIA: experimental studies involving oocytes, spermatozoa, or embryos in vitro/in vivo. EXCLUSION CRITERIA: review articles, letters to the editor, abstracts, books, and studies outside the scope. Extracted data included the type of venom, source species, experimental model, effects, mechanisms, and administration routes. Methodological quality was assessed using funnel plots, forest plots, and the SYRCLE tool. Computational screening was performed targeting hormonal receptors.
resultsOf the 584 articles analyzed, only 19 met the eligibility criteria. Among these, 57% investigated snake venom, 16% spider venom, 16% bee venom, and 10% sea anemone/scorpion venom. High heterogeneity was observed in the effects on sperm motility (I² = 97%) and sperm concentration (I² = 95%), although a positive effect on concentration was detected. All molecules showed activity on estrogen receptors. DISCUSSION: The findings suggest that venoms and their derivatives can modulate gamete functions, with effects influenced by the chemical diversity of toxins and variations in experimental models. Computational screening highlights potential molecular interactions with hormonal pathways, reinforcing their relevance as modulators of reproductive processes.
conclusionAnimal venoms and their derivatives can exert biological activity on germ cells (oocytes, spermatozoa, and embryos).
Indexed as
Identifiers
41177790What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.