ReviewExperimental & molecular medicine2025
The role of coinhibitory receptor-expressing non-T cells in inflammation and immunity: unsung heroes or peripheral players?
Review in Experimental & molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Tissue-resident Limosilactobacillus reuteri modulates intratumoral arachidonic acid metabolism to enhance CD8Journal of translational medicine · 2026Article
- Harnessing tumor immune checkpoints for autoimmune disease therapeutics.Frontiers in immunology · 2026Review
- Regulatory T cell dysfunction and exhaustion in uveitis: immunometabolic mechanisms, microenvironmental drivers, and emerging therapeutic strategies.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Immune responses are finely regulated by multiple mechanisms, among which immune regulatory coreceptor family molecules play a central role in both enhancing and suppressing immune responses. Traditionally, T cells have been considered the primary cell type expressing these receptors, through which their responses are modulated. This understanding led to the emergence of the field of 'immune checkpoint blockade', which aims to rejuvenate T cells that have become exhausted in the context of chronic infections or the tumor environments. The molecules targeted by such approaches include PD1, CTLA4, Lag3, Tim3 and TIGIT, coinhibitory receptors predominantly expressed on conventional T cells exhibiting functionally impaired, exhausted phenotypes. Interestingly, an expanding array of non-T cell types also express these receptors, although their specific roles remain largely elusive. Here we explore the immune regulatory functions of these coreceptors as expressed on non-conventional T cells, such as myeloid cells and B cells, highlighting their potential contributions to immune regulation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.