Evidence map›Paper›PMID 41178744›Full record

ArticleDiabetes, obesity & metabolism2026

Cardiorespiratory fitness and type 2 diabetes risk: A prospective cohort study with mediation analysis of biological aging in the UK Biobank.

Xiangliang Liu, Xinqiao Chen, Wang Yang, Guanran Ding, Yixin Zhao, Yuguang Li, Naifei Chen, Jiuwei Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiangliang LiuCancer Center, The First Hospital of Jilin University, Changchun, China.
Xinqiao ChenCancer Center, The First Hospital of Jilin University, Changchun, China.
Wang YangCancer Center, The First Hospital of Jilin University, Changchun, China.
Guanran DingCancer Center, The First Hospital of Jilin University, Changchun, China.
Yixin ZhaoCancer Center, The First Hospital of Jilin University, Changchun, China.
Yuguang LiCancer Center, The First Hospital of Jilin University, Changchun, China.
Naifei ChenCancer Center, The First Hospital of Jilin University, Changchun, China.ORCID 0000-0002-8625-5121
Jiuwei CuiCancer Center, The First Hospital of Jilin University, Changchun, China.

Funding

Department of Science and Technology of Jilin Province YDZJ202401227ZYTS
6 · The paper itself

Abstract

aimsHigher cardiorespiratory fitness is associated with reduced type 2 diabetes mellitus (T2D) risk, but the underlying mechanisms remain incompletely understood. We investigated whether biological aging mediates the association between maximal oxygen uptake (VO MATERIALS AND

methodsThis prospective cohort study included 54 418 UK Biobank participants aged 39-70 years without baseline diabetes. VO

resultsDuring 694 986 person-years of follow-up, 2628 participants developed T2D (incidence rate: 3.78 per 1000 person-years). Compared to the lowest VO

conclusionsHigher cardiorespiratory fitness demonstrates robust protective associations against T2D incidence, with biological aging mechanisms partially mediating this relationship.

Indexed as

AgingCardiorespiratory FitnessDiabetes Mellitus, Type 2AdultAgedBiological Specimen BanksBiomarkersFemaleHumansIncidenceMaleMediation AnalysisMiddle AgedOxygen ConsumptionProspective StudiesRisk FactorsBiomarkersbiological agingcardiorespiratory fitnessmaximal oxygen uptakemediation analysisprimary preventionprospective cohort studytype 2 diabetes mellitusUK Biobank

Identifiers

PMID41178744
PMCPMC12803562

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.