ArticleWorld journal of gastrointestinal surgery2025
Study on the neuroimmune regulatory mechanism of electroacupuncture at Zusanli acupoint for postoperative intestinal paralysis after gastrointestinal surgery.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Acupuncture regulating the gut-brain axis for postoperative ileus: Neuroimmune mechanisms and clinical translation prospects.World journal of gastrointestinal surgery · 2026Article
- Bridging Traditions: Integrating TCM Into ERAS for Enhanced Gastrointestinal Recovery -A Scoping Review.Drug design, development and therapy · 2026Article
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Abstract
backgroundPostoperative intestinal paralysis is common in gastrointestinal surgery, and the study of electroacupuncture mechanisms is of great significance.
aimTo explore the neuroimmune regulatory mechanism of electroacupuncture at the Zusanli acupoint (ST36) in postoperative intestinal paralysis following gastrointestinal surgery.
methodsA total of 156 patients admitted to the Affiliated Hospital of Jiangnan University between January 2022 and October 2024 for postoperative intestinal paralysis following gastrointestinal surgery were randomly divided into two groups: A control group and an electroacupuncture group, with 75 patients in each. The control group received conventional Western medical treatment, while the electroacupuncture group received electroacupuncture in addition to this, at the bilateral Zusanli acupoints. Both groups received treatment for 7 days. Clinical efficacy, gastrointestinal function recovery, and gastrointestinal hormone [motilin (MTL), gastrin (GAS)], neurotransmitter [vasoactive intestinal peptide (VIP), nitric oxide (NO)], and inflammatory cytokine [tumor necrosis factor-α (TNF-α), serum interleukin-6 (IL-6), interleukin-1β (IL-1β)] levels were compared between the two groups before and seven days after treatment. Adverse reactions were also recorded.
resultsThe electroacupuncture group demonstrated a higher overall treatment effectiveness rate and faster recovery of bowel sounds, as well as faster first defecation and first flatus than the control group (
conclusionElectroacupuncture at the Zusanli acupoint can enhance clinical efficacy, promote the recovery of gastrointestinal function, and regulate the neuroimmune microenvironment in patients with intestinal paralysis after gastrointestinal surgery. This mechanism may involve excitation of the vagus nerve and activation of the cholinergic anti-inflammatory pathway through electroacupuncture stimulation of the Zusanli acupoint.
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