Evidence map›Paper›PMID 41178995›Full record

ArticleGut microbiome (Cambridge, England)2025

Impact of non-nutritive sweeteners on bacterial quorum sensing and phenotypic expression: implications for gut microbiome dynamics.

Mindani Watawana, Emilia Maria Franca Lima, Beatriz Ximena Valencia Quecan, Max Sherry, Daniel Granato, Achim Schmalenberger, Christian Hoffmann, Uelinton M Pinto, Fabiana Andrea Hoffmann Sarda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbiome (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mindani WatawanaDepartment of Biological Sciences, Faculty of Science and Engineering, University of Limerick, Limerick, Ireland.
Emilia Maria Franca LimaFood Research Center (FoRC), Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil.
Beatriz Ximena Valencia QuecanFood Research Center (FoRC), Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil.
Max SherryDepartment of Biological Sciences, Faculty of Science and Engineering, University of Limerick, Limerick, Ireland.
Daniel GranatoDepartment of Biological Sciences, Faculty of Science and Engineering, University of Limerick, Limerick, Ireland.
Achim SchmalenbergerDepartment of Biological Sciences, Faculty of Science and Engineering, University of Limerick, Limerick, Ireland.
Christian HoffmannFood Research Center (FoRC), Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil.
Uelinton M PintoFood Research Center (FoRC), Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil.
Fabiana Andrea Hoffmann SardaDepartment of Biological Sciences, Faculty of Science and Engineering, University of Limerick, Limerick, Ireland.ORCID https://orcid.org/0000-0003-2807-5605

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-nutritive sweeteners (NNSs) are popular sugar substitutes, valued for their potential to reduce caloric intake and associated health risks. However, their long-term effects on the human gut microbiome remain debatable. This study investigates the impact of tagatose, allulose, Rebaudioside-A (Reb-A), and saccharin on quorum-sensing (QS)-regulated phenotypes and gene expression in QS biosensor model bacteria. It sheds light on their potential influence on the gut microbiome. Our study revealed diverse effects among the NNSs. Tagatose and allulose demonstrated QS phenotypic inhibition in

Indexed as

alluloseChromobacterium violaceumPseudomonas aeruginosaRebaudioside-Asaccharintagatose

Identifiers

PMID41178995
PMCPMC12571687

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.