Evidence map›Paper›PMID 41179172›Full record

ArticleACS omega2025

Affinity Selection-Mass Spectrometry for the Identification of Ligands of Acetylcholinesterase from

Larissa Ramos Guimarães da Silva, Christyne Barros de Sá, Bruno Sergio do Amaral, Nelilma Correia Romeiro, Quezia Bezerra Cass, Alessandra Leda Valverde

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In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Larissa Ramos Guimarães da SilvaLaboratório de Produtos Naturais (LaProMar), Instituto de Química, Universidade Federal Fluminense, Niterói, RJ 24020-005, Brazil.
Christyne Barros de SáLaboratório Integrado de Computação Científica - LICC, Centro Multidisciplinar da UFRJ Macaé, Universidade Federal do Rio de Janeiro, Macaé, RJ 27930-560, Brazil.
Bruno Sergio do AmaralInstituto Federal de Educação, Ciência e Tecnologia de São Paulo, Campus Pirituba, São Paulo, SP 01109-010, Brazil.
Nelilma Correia RomeiroLaboratório Integrado de Computação Científica - LICC, Centro Multidisciplinar da UFRJ Macaé, Universidade Federal do Rio de Janeiro, Macaé, RJ 27930-560, Brazil.ORCID https://orcid.org/0000-0003-2562-8331
Quezia Bezerra CassInstituto Federal de Educação, Ciência e Tecnologia de São Paulo, Campus Pirituba, São Paulo, SP 01109-010, Brazil.ORCID https://orcid.org/0000-0002-6550-1194
Alessandra Leda ValverdeLaboratório de Produtos Naturais (LaProMar), Instituto de Química, Universidade Federal Fluminense, Niterói, RJ 24020-005, Brazil.ORCID https://orcid.org/0000-0002-1250-1051

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetylcholinesterase (AChE) inhibition has been successful for the treatment of Alzheimer's disease and still stands as an important target in the search for novel ligands. In this context, affinity selection-mass spectrometry (AS-MS) has been acknowledged as a high-throughput screening (HTS) technique for large molecular libraries in drug discovery programs and natural product investigations. In this work, an AS-MS assay with AChE immobilized onto magnetic beads (AChE-MB) has been used to search for ligands in samples of the sponge

Identifiers

PMID41179172
PMCPMC12573006

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.