ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Relationship Between the TyGH Index (Based on Triglycerides and HbA1c) and Diabetic Kidney Disease in Patients with Type 2 Diabetes: A Real-World Study.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The triglyceride-glucose index (TyG index) is significantly associated with diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D). Glycated hemoglobin A1c (HbA1c) is more stable and repeatable than fasting plasma glucose. Limited studies have combined HbA1c and triglyceride (TG) to investigate their relationship with DKD in patients with T2D. We aimed to investigate the association of the triglyceride-glycated hemoglobin (TyGH) index with DKD risk in Chinese adults with T2D compared with the TyG index. Methods: This was a cross-sectional observational study that included 2721 patients with T2D. Demographic, anthropometric, and laboratory measurements were collected. An endocrinologist diagnosed DKD based on the data from the estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (UACR). The TyGH index was determined as ln(TG [mg/dL] × HbA1c [%] * 18/2), and the TyG index was calculated as ln(TG [mg/dL] × FPG [mg/dL]/2). Results: The prevalence values of DKD from the lowest to the highest tertile of the TyGH index were 29.7%, 35.2%, and 38.9%, respectively. The TyGH index was significantly higher in participants with macro- and microalbuminuria than in those with normoalbuminuria. In the multivariable logistic analyses, each unit of the TyGH index was associated with a 1.59-fold (1.33-1.90, Conclusion: Compared with the TyG index, the TyGH index demonstrates a stronger and more independent association with DKD in patients with T2D, suggesting its potential as a superior clinical biomarker.
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