Evidence map›Paper›PMID 41179607›Full record

ArticleClinical case reports2025

Challenges in Diagnosis and Management of Ovarian Neuroendocrine Carcinoma: A Case of Aggressive Disease With Multimodal Treatment Approach.

Javeria Haider, Humera Mahmood, Muhammad Faheem, Shaista Khurshid, Abdullah, Biruk Demisse Ayalew, Humza Saeed

Abstract read
In one paragraph

Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Javeria HaiderDepartment of Oncology Atomic Energy Cancer Hospital NORI Islamabad Pakistan.
Humera MahmoodDepartment of Oncology Atomic Energy Cancer Hospital NORI Islamabad Pakistan.
Muhammad FaheemDepartment of Oncology Atomic Energy Cancer Hospital NORI Islamabad Pakistan.
Shaista KhurshidDepartment of Oncology Atomic Energy Cancer Hospital NORI Islamabad Pakistan.
AbdullahDepartment of Internal Medicine Rawalpindi Medical University Rawalpindi Punjab Pakistan.
Biruk Demisse AyalewSt. Paul's Hospital Millennium Medical College Addis Ababa Ethiopia.ORCID https://orcid.org/0009-0006-8285-6233
Humza SaeedDepartment of Internal Medicine Rawalpindi Medical University Rawalpindi Punjab Pakistan.ORCID https://orcid.org/0009-0003-0256-4272

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine tumors (NETs) of the ovary are extremely rare, accounting for only 1%-2% of malignant ovarian tumors, with high-grade subtypes demonstrating particularly aggressive behavior. We describe a 47-year-old woman who presented with abdominal swelling, irregular bleeding, and pain, and was diagnosed with high-grade ovarian neuroendocrine carcinoma following surgical resection. Despite initial treatment with paclitaxel and carboplatin, residual disease persisted, prompting therapy with long-acting Sandostatin. The disease subsequently progressed with hepatic and peritoneal involvement, and she was successfully managed with cisplatin and etoposide. This case illustrates the diagnostic complexity and aggressive course of ovarian neuroendocrine carcinoma and underscores the importance of individualized, multimodal treatment strategies and vigilant follow-up in the absence of standardized guidelines.

Indexed as

carboplatinchemotherapycisplatinetoposideneuroendocrine tumorsovarianpaclitaxel

Identifiers

PMID41179607
PMCPMC12572728

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.