Evidence map›Paper›PMID 41179736›Full record

ArticleWorld journal of hepatology2025

Ginger mitigates acrylamide-induced hepatotoxicity through antioxidant and anti-inflammatory mechanisms in rats.

Ahmed El-Sayed Nour El Deen, Fatma Rashed, Amira Osman, Osama Khalil Farag, Ahmed F Abdel Ghany, Almoatazbellah Mahmoud Elsayed, Sherif M A Mansour, Mohammed Abdel Aziz Mohammed, Reda S Taha, Sami Ahmed Zaher Basha and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ahmed El-Sayed Nour El DeenDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Assuit 002, Egypt.
Fatma RashedDepertment of Oral Biology, Faculty of Dentistry, Damanhour University, Behera 2025, Egypt.
Amira OsmanDepartment of Anatomy and Histology, Faculty of Medicine, Mutah University, Karak 61710, Jordan.
Osama Khalil FaragDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Assuit 002, Egypt.
Ahmed F Abdel GhanyDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Assuit 002, Egypt.
Almoatazbellah Mahmoud ElsayedDepartments of Basic Medical and Clinical Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa 00962, Jordan.
Sherif M A MansourDepartment of Pharmacology, Faculty of Medicine, Al-Azhar University, Assuit 002, Egypt.
Mohammed Abdel Aziz MohammedDepartment of Physiology, Faculty of Medicine, Al-Azhar University, Assuit 002, Egypt.
Reda S TahaDepartments of Basic Medical and Clinical Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa 00962, Jordan.
Sami Ahmed Zaher BashaDepartment of Physical Therapy, Faculty of Allied Medical Sciences, Zarqa University, Zarqa 00962, Jordan.
Mostafa Mahmoud Youssef MohamedDepartments of Basic Medical and Clinical Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa 00962, Jordan.
Ahmad TahaDepartments of Basic Medical and Clinical Dental Sciences, Faculty of Dentistry, Zarqa University, Zarqa 00962, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcrylamide (ACR), a toxic compound commonly found in heat-processed foods, poses a serious risk to liver health due to its oxidative and inflammatory effects.

aimTo evaluate the hepatoprotective potential of ginger extract in mitigating ACR-induced liver toxicity in a rat model.

methodsMale Sprague-Dawley rats were randomly assigned into control, ACR-treated, and ACR + ginger-treated groups. Liver function enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP)], oxidative stress biomarkers [malondialdehyde (MDA), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD)], and histopathological assessments were performed. In addition, gene expression analyses of key antioxidant and inflammatory markers were conducted using quantitative polymerase chain reaction.

resultsACR administration significantly increased serum levels of ALT, AST, ALP, and MDA, while reducing levels of GSH, CAT, and SOD. Histological analysis revealed hepatic degeneration and inflammation. Co-administration of ginger extract significantly reversed these effects, restoring antioxidant enzyme levels, reducing oxidative stress, and improving liver histoarchitecture.

conclusionGinger extract exhibited strong hepatoprotective effects against ACR-induced toxicity through antioxidant and anti-inflammatory mechanisms. These findings support the potential role of ginger as a natural dietary intervention for mitigating liver damage caused by environmental toxins. Further clinical studies are recommended to confirm its efficacy in human populations.

Indexed as

AcrylamideAntioxidantsGingerHepatotoxicityOxidative

Identifiers

PMID41179736
PMCPMC12576710

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.