ArticleFrontiers in medicine2025
Clinical impact of collagen sponge combined with substance P on maxillofacial trauma repair in rats.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Collagen sponge and substance P (SP) can facilitate trauma healing. Therefore, this study aimed to clarify the role and mechanism of collagen sponge combined with SP in maxillofacial trauma healing. Methods: A maxillofacial trauma model was established using rats. The rats were divided into four groups: research group 1 (RG 1; Vaseline gauze and SP), research group 2 (RG 2; Vaseline gauze and collagen sponge), research group 3 (RG 3; collagen sponge and SP), and a control group (CG; Vaseline gauze and normal saline). The trauma healing rate was examined on days 3, 7, and 14 after treatment, and the pathological morphology of the trauma was examined on day 14 after treatment. Hydroxyproline expression; positive expression of basic fibroblast growth factor (bFGF); serum IL-6 and TNF- Results: On days 7 and 14 after treatment, the trauma healing rates in all research groups were higher than that in the CG, and the trauma healing rate in RG 3 was higher than that in RG 1 and RG 2. On day 14 after treatment, compared to the CG, the number of inflammatory cells in the rat trauma tissues was reduced in all research groups, while the collagen fiber content was enhanced in all research groups. Compared to RG 1 and RG 2, the number of inflammatory cells in RG 3 was lower, while the collagen fiber content in RG 3 was higher. The tissue hydroxyproline and bFGF levels in all research groups were higher than those in the CG, and the levels in RG 3 were higher than those in RG 1 and RG 2. Compared to the CG, serum levels of IL-6 and TNF- Conclusion: Collagen sponge and SP can facilitate the healing of maxillofacial trauma and reduce scar formation after trauma healing. This effect may be related to the TGF-β1/Smad3-VEGF signaling pathway.
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