SynthesisFrontiers in medicine2025
The effect of metformin in clinical studies on knee osteoarthritis: an updated systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Metformin is regarded as a potential drug for the treatment of knee osteoarthritis (KOA), but its efficacy remains unclear. This systematic review and meta-analysis aims to evaluate the efficacy of metformin in the treatment of KOA. Methods: According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched three literature databases, including PubMed, Web of Science and EMBASE, and conducted a systematic review and meta-analysis of randomized controlled trials and cohort studies up to April 1, 2025, studies evaluating the use of metformin in the treatment of KOA were included. Hazard ratio (RR), standard mean difference (SMD), and the corresponding 95% confidence interval (CI) were used as aggregated statistics. This systematic review is registered on RROSPERO (CRD420251026750). Results: A total of six eligible studies included 4,628 patients (1,489 patients use metformin versus 3,139 patients non-use). The main observation outcome was the score of the pain scale (WOMAC, KOOS, VAS, etc.) of the knee joint and the incidence of total knee arthroplasty (TKA) is a secondary outcome. Analysis of the included population the included population reveals that the BMI levels of all individuals were at the overweight range. In this situation, the comprehensive results show that regardless of different conventional treatment methods, courses of treatment and doses, combined metformin treatment in the incidence of joint replacement [RR = 0.65, 95% CI (0.54, 0.77), Conclusion: The research results show that metformin can relieve the pain of KOA with high BMI and reduce the possibility of joint replacement. However, due to the less of randomized controlled trials (RCTS), clinicians should be fully cautious when using it. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251026750.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.