ArticleFrontiers in endocrinology2025
The ratio of extracellular water to total body water serves as a potential predictor of diabetic peripheral neuropathy in patients.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Subclinical overhydration predicts lower time in range and greater glycemic variability in type 2 diabetes on hemodialysis.Scientific reports · 2026Article
- Predictive equations commonly used in the clinic underestimate resting energy expenditure compared with whole-room indirect calorimetry in colorectal cancer survivors.The American journal of clinical nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diabetic peripheral neuropathy (DPN), a common chronic complication of type 2 diabetes mellitus (T2DM), lacks simple biomarkers for early monitoring. This study aimed to explore the association between the ratio of extracellular water to total body water (ECW/TBW) and DPN. Methods: A total of 707 T2DM patients recruited from the Third Affiliated Hospital of Soochow University were included in this cross-sectional study. Multivariate logistic regression analyses were performed to assess the association between the ECW/TBW ratio and DPN after adjusting. Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of the ECW/TBW ratio for DPN. Results: The risk of DPN is related significantly with ECW/TBW ratio by multivariate logistic regression analyses, especially the ECW/TBW ratio of arms, trunk, and legs. And the ECW/TBW ratio can not be a indicator to predict the DPN rick of whose BMI is above 28kg/m². Besides, adding the ECW/TBW ratio to the baseline model gained a positive change in the integrated discrimination improvement and continuous net reclassification improvement. The area under the curve (AUC) of ECW/TBW (AUC:0.678) was higher than that of Neutrophil-to-Lymphocyte Ratio (NLR, AUC:0.620) and Platelet-to-Lymphocyte Ratio (PLR, AUC:0.568). Conclusions: The ratio of ECW/TBW exhibits a potential predictive capacity for DPN and better than NLR and PLR in T2DM patients with BMI <28 kg/m².
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.