Evidence map›Paper›PMID 41180481›Full record

ArticlePeerJ2025

Single-particle analysis of small extracellular vesicles from human follicular fluid unveils immunomodulatory PD-L1

Barbara Bortot, Roberta Di Florio, Gabriella Zito, Francesco Valle, Marco Brucale, Giuseppe Ricci, Paola Vigano, Stefania Biffi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Barbara BortotObstetrics and Gynaecology Department, IRCCS Materno Infantile Burlo Garofolo, Trieste, Italy.
Roberta Di FlorioObstetrics and Gynaecology Department, IRCCS Materno Infantile Burlo Garofolo, Trieste, Italy.
Gabriella ZitoObstetrics and Gynaecology Department, IRCCS Materno Infantile Burlo Garofolo, Trieste, Italy.
Francesco ValleInstitute of Nanostructured Materials, Istituto per lo Studio dei Materiali Nanostrutturati, Consiglio Nazionale delle Ricerche, Unitá Operative di Supporto di Bologna, Bologna, Italy.
Marco BrucaleInstitute of Nanostructured Materials, Istituto per lo Studio dei Materiali Nanostrutturati, Consiglio Nazionale delle Ricerche, Unitá Operative di Supporto di Bologna, Bologna, Italy.
Giuseppe RicciObstetrics and Gynaecology Department, IRCCS Materno Infantile Burlo Garofolo, Trieste, Italy.
Paola ViganoInfertility Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Stefania BiffiObstetrics and Gynaecology Department, IRCCS Materno Infantile Burlo Garofolo, Trieste, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In certain cell systems, small extracellular vesicles bearing PD-L1 (PD-L1

Indexed as

B7-H1 AntigenExtracellular VesiclesFertilityFollicular FluidAdultBiomarkersFemaleHumansTetraspanin 28Tetraspanin 29Tetraspanin 30B7-H1 AntigenBiomarkersCD274 protein, humanCD9 protein, humanTetraspanin 28Tetraspanin 29Tetraspanin 30Atomic force microscopyFollicular fluidPD-L1Single-particle analysisSmall extracellular vesicles

Identifiers

PMID41180481
PMCPMC12577570

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.