ArticleFrontiers in neurology2025
SynthSR-generated 3D T1-weighted MRI from routine 2D clinical images: Validation for VSRAD analysis.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The Voxel-based Specific Regional Analysis System for Alzheimer's Disease (VSRAD), a voxel-based morphometry tool quantifying medial temporal lobe atrophy as region-specific Methods: In this retrospective single-center study, MRI data from 75 patients were analyzed using both standard 3D T1-weighted images and SynthSR-generated 3D volumes reconstructed from 2D T1-weighted sequences. Regional brain volumes and four key Z-score indices from VSRAD were compared using Wilcoxon signed-rank tests with Bonferroni correction, robust Bland-Altman analysis, Spearman's rank correlation, and receiver operating characteristic (ROC) curve analysis focusing on Score 1 "Severity." Results: All Z-score indices and segmented volumes showed significant absolute differences between the two methods ( Conclusion: Although SynthSR-based images produced systematically different absolute values, they preserved rank-order correlations and maintained diagnostic performance comparable to that of standard 3D volumes in VSRAD analysis. Considering that conventional 3D acquisitions are often difficult to obtain in elderly patients undergoing dementia screening, SynthSR-based reconstruction may represent a practical alternative in routine clinical practice, particularly for Score 1 "Severity," the most clinically relevant marker of hippocampal atrophy.
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