ArticleJournal of experimental orthopaedics2025
Blood flow restriction training before platelet-rich plasma preparation induces a significant reduction in its interleukin-6 levels: A pilot randomised controlled trial.
Article in Journal of experimental orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Blood flow restriction training before platelet-rich plasma preparation induces a significant reduction in its interleukin-6 levels: A pilot randomised controlled trial.Journal of experimental orthopaedics · 2025Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Purpose: To assess platelet-rich plasma (PRP) changes in platelet and leucocyte count, insulin-like growth factor (IGF-1) and interleukin 6 (IL-6) concentration after bilateral low-load knee extensions with blood flow restriction (BFR). Methods: A randomised controlled trial involving two groups was conducted. The intervention group underwent low-load bilateral knee extensions with BFR, while the control group without BFR. Inclusion criteria were (1) male individuals, (2) between 18 and 40 years, (3) with Tegner activity level ≥5 and (4) no musculoskeletal conditions that would interfere with exercise. The participant performed a standard protocol of 30-15-15-15 repetitions of consecutive sets with 30-s rest intervals at 80% of limb occlusive pressure and a 15-lb load. PRP platelet and leucocyte count, IGF-1 and IL-6 concentration measurements (via flow cytometry, chemiluminescence testing and immunochromatography, respectively) were conducted before exercise and 10, 20 and 30 min after the intervention (T1, T2, T3 and T4, respectively). Results: A total of 24 participants were enrolled and allocated into two groups. The exercise bout in the BFR group resulted in higher platelet concentration and dose at T2 and T3, reaching a mean 9.9% maximum concentration increase and a mean 15.6% maximum dose increase at T2 ( Conclusion: Low-load bilateral knee extensions with BFR induced a significant reduction of IL-6 concentration in PRP, which holds potential to tailor treatment for specific musculoskeletal injuries. Level of Evidence: Level I.
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