ArticleFrontiers in aging neuroscience2025
Elevated gonadotropins and risk of dementia in Chinese adults aged over 80: a cross-sectional study.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Advancing Alzheimer's disease research in China: insights, innovations, and future directions from the chinese preclinical Alzheimer's disease study (CPAS).Molecular psychiatry · 2026Review
- Longitudinal trajectories of cognitive decline and temporal lobe atrophy based on baseline gonadotropins and testosterone.Frontiers in neuroscience · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Age-related elevation of gonadotropins may contribute to cognitive decline, while apolipoprotein E epsilon 4 (APOE ε4) is an established risk factor for Alzheimer's disease (AD). This study investigated the associations of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels with global cognition and dementia in adults aged over 80. Methods: A total of 509 adults (440 males and 69 females) were included in this cross-sectional analysis, comprising 337 with normal cognition (NC), 97 with Alzheimer's disease-related dementia (AD-D), and 75 with vascular dementia (VD). Cognitive status was assessed using Mini-Mental State Examination (MMSE). Plasma gonadotropins and sex hormones were measured by chemiluminescence. Multivariable linear and logistic regression models, adjusted for potential confounders, were employed. Results: Follicle-stimulating hormone concentrations were significantly elevated in males with dementia and females with VD compared to NC. LH concentrations were significantly elevated in VD across sexes compared with NC. Neither estradiol nor total testosterone differed across groups. Continuous LH, rather than FSH, was significantly associated with MMSE scores in the total cohort and males after adjusting covariates (both Conclusion: Elevated FSH and reduced LH may be associated with poorer cognition and an increased risk of AD-D in very old Chinese adults, particularly in males.
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