ArticleLaryngoscope investigative otolaryngology2025
Eucalyptol (1,8-Cineole) Enhances Wound Healing in Nasal Septal Perforations: An Experimental Rat Model Study.
Article in Laryngoscope investigative otolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to investigate the therapeutic effects of eucalyptol (1,8-cineole), a natural monoterpene oxide with known anti-inflammatory and antioxidant properties, on the healing of nasal septal perforations (NSPs) using an experimental rat model. The study evaluated macroscopic closure rates, histological changes, and inflammation-related outcomes. Methods: A total of 22 Sprague Dawley rats were used to create a standardized NSP model. The animals were randomly divided into two groups: a control group ( Results: Macroscopic closure occurred in 100% of the eucalyptol group vs. 45.5% of controls ( Conclusion: Eucalyptol significantly improved both macroscopic and histological healing outcomes in NSPs. Its anti-inflammatory, antioxidant, and pro-regenerative effects suggest that eucalyptol may serve as a promising and non-invasive therapeutic agent in the management of nasal septal perforations. Level of Evidence: Level 3.
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