ArticleNature. Mental health2025
Brain dynamics reflecting an intra-network brain state is associated with increased posttraumatic stress symptoms in the early aftermath of trauma.
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Article in Nature. Mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7citing papers in PubMed
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Who cites it
7 citing papers in PubMed.
- Characteristic spatiotemporal features of large-scale functional network architecture in posttraumatic stress disorder.Translational psychiatry · 2026Article
- Learning brain dynamics across distinct scaling regimes reveals psychiatric signatures.Communications biology · 2026Article
- Dynamic Brain Age Modeling Identifies Network-Specific Cognitive Deficits in Schizophrenia.Research square · 2025Article
- State-Guided ICA of Functional Network Connectivity Reveals Temporal Signatures of Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2025Article
- Comprehensive mapping of cognitive and emotion networks in stress, anxiety, and depression implicates the precuneus as a critical hub.Research square · 2025Article
- Functional Brain Age Acceleration from Dynamic and Static Connectivity Predicts Working Memory and Attention Deficits in Schizophrenia.medRxiv : the preprint server for health sciences · 2025Article
- Towards predicting posttraumatic stress symptom severity using portable EEG-derived biomarkers.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
50 authors.
Mohammad Se SendiDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Zening FuTri-Institutional Center for Translationaal Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Nathaniel G HarnettDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Victor VergaraTri-Institutional Center for Translationaal Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Diego A PizzagalliDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Nikolaos P DaskalakisDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Francesca L BeaudoinDepartment of Epidemiology, Brown University, Providence, RI, 02930, USA.
Xinming AnInstitute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Thomas C NeylanDepartments of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, 94143, USA.
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, 30332, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, 48202, USA.
Sarah D LinnstaedtInstitute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Laura T GermineInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA, 02478, USA.
Kenneth A BollenDepartment of Psychology and Neuroscience & Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Scott L RauchDepartment of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA.
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Health System, Detroit, MI, 48202, USA.
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.
Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.
Christopher W JonesDepartment of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, 08103, USA.
Brittany E PunchesDepartment of Emergency Medicine, Ohio State University College of Medicine, Columbus, OH, 43210, USA.
Robert A SworDepartment of Emergency Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI, 48309, USA.
Nina T GentileDepartment of Emergency Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19121, USA.
Vishnu P MurtyDepartment of Psychology, Temple University, Philadelphia, PA, 19121, USA.
Lauren A HudakDepartment of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Jose L PascualDepartment of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Mark J SeamonPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Erica HarrisDepartment of Emergency Medicine, Einstein Medical Center, Philadelphia, PA, 19107, USA.
Anna M ChangDepartment of Emergency Medicine, Jefferson University Hospitals, Philadelphia, PA, 19107, USA.
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, MI, 48202, USA.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Roland C MerchantDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Robert M DomeierDepartment of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, MI, 48197, USA.
Niels K RathlevDepartment of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, 01107, USA.
Brian J O'NeilDepartment of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI, 48202, USA.
Paulina SergotDepartment of Emergency Medicine, McGovern Medical School at UTHealth, Houston, TX, 77030, USA.
Leon D SanchezDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Steven E BruceDepartment of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, 63121, USA.
John F SheridanDivision of Biosciences, Ohio State University College of Dentistry, Columbus, OH, 43210, USA.
Steven E HarteDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, 02115, USA.
Karestan C KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, 02115, USA.
Samuel A McLeanDepartment of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Vince D CalhounTri-Institutional Center for Translationaal Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Kerry J ResslerDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Funding
Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8MEarly Life Stress and Depression: Molecular and Functional Imaging ApproachesR01MH095809 · NIMH · MCLEAN HOSPITAL · PI DU, FEI, PIZZAGALLI, DIEGO A · 2012 to 2024
$6.4MExtracellular vesicles as biomarkers of trauma exposure and PTSD riskR01MH129495 · NIMH · UNIVERSITY OF COLORADO DENVER · PI Tracy L Bale, Tanja Jovanovic · 2022 to 2026
$4.0MMobile Measures of Threat Sensitivity for Cross-sectional and Longitudinal AssessmentR01MH121617 · NIMH · MCLEAN HOSPITAL · PI GERMINE, LAURA THI · 2020 to 2025
$3.9MIndividual Variation in Effects of Traumatic Stress on Gray Matter MyelinR01MH115020 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI KAUFER, DANIELA, NEYLAN, THOMAS C · 2019 to 2023
$3.9MFacilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSDR01MH122867 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ANN M. RASMUSSON · 2020 to 2026
$3.6MData-driven solutions for temporal, spatial, and spatiotemporal dynamic functional connectivityR01MH123610 · NIMH · GEORGIA STATE UNIVERSITY · PI ADALI, TULAY, CALHOUN, VINCE D · 2021 to 2025
$3.1MInvestigating Fear System Myelination in PTSD Using In Vivo and Post Mortem DataR01MH132617 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI HUBER, BERTRAND R, NEYLAN, THOMAS C · 2023 to 2025
$2.1MTraining to Enhance Alignment of Psychiatry and NeuroscienceT32MH125786 · NIMH · MCLEAN HOSPITAL · PI William A. Carlezon, KERRY J. RESSLER · 2021 to 2026
$2.0MEffect of TMS on PTSD Neuroimaging and Psychophysiological BiomarkersK01MH121653 · NIMH · EMORY UNIVERSITY · PI VAN ROOIJ, SANNE JH · 2020 to 2024
$894kMultimodal characterization of affective visual processing in the early aftermath of traumaK01MH129828 · NIMH · MCLEAN HOSPITAL · PI Nathaniel G Harnett · 2023 to 2026
$719kNIMH NIH HHS K01 MH121653NIMH NIH HHS K01 MH129828NIMH NIH HHS R01 MH095809NIMH NIH HHS R01 MH115020NIMH NIH HHS R01 MH121617NIMH NIH HHS R01 MH122867NIMH NIH HHS R01 MH123610NIMH NIH HHS R01 MH129495NIMH NIH HHS R01 MH132617NIMH NIH HHS T32 MH125786NIMH NIH HHS U01 MH110925
Abstract
Post-traumatic stress (PTS) encompasses a range of psychological responses following trauma, which may lead to more severe outcomes such as post-traumatic stress disorder (PTSD). Identifying early neuroimaging biomarkers that link brain function to PTS outcomes is critical for understanding PTSD risk. This longitudinal study examines the association between brain dynamic functional network connectivity (dFNC) and current/future PTS symptom severity, and the impact of sex on this relationship. By analyzing 275 participants' dFNC data obtained ~2 weeks after trauma exposure, we noted that brain dynamics of an inter-network brain state link negatively with current (
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