ReviewAnnals of medicine and surgery (2012)2025
Innovative animal models for surgical interventions and implant biocompatibility: a translational perspective.
Review in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Innovative animal models are instrumental in translating surgical and implant technologies, serving as bridges for surgical intervention and implant biocompatibility from preclinical research to clinical translation. This review discusses genetically modified, disease-specific, and biomimetic animal models used for orthopedic, cardiovascular, neural, and soft tissue implants. Quantitative comparisons have shown 45% impaired bone regeneration of CRISPR- engineered osteoporotic rodents, enabling exact evaluation of highly bioactive scaffolds. Humanized porcine models for vascular implants show similar 30% endothelialization improvement which reduce thrombosis risks, and enhance implant longevity. These advanced polymeric coatings were also able to reduce chronic rejection by 50% as measured in immune-humanized mouse models emphasizing the role of inflammatory response in qualitative analyses. Diabetic animal models with biosensor-integrated implants show 60% quicker wounds healing, underscoring the potential complement of smart implants and individualized preclinical experimentation. These advances have brought new challenges in genetic drift, long-term stability, and low regulatory standardization. The advancements of AI-assisted device selection, 3D bioprinting of those selected devices, and in vivo imaging of the devices, may prove to be the most promising for future studies. This review outlines a translational roadmap to intermediate cards with implant success and accelerates the clinical translation of next generation surgical technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.