Evidence map›Paper›PMID 41181985›Full record

ArticleClinical nursing research2025

Post-COVID-19 Consequences in Relatives of Severely Ill Patients: Results of the Prospective Multicenter NeNeSCo Study.

Simona Klinkhammer, Caroline van Heugten, Susanne van Santen, Annelien A Duits, Janneke Horn, Arjen Jc Slooter, Esmée Verwijk, Johanna Ma Visser-Meily

Abstract readMulticenter Study
In one paragraph

Article in Clinical nursing research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Simona KlinkhammerMaastricht University, the Netherlands.
Caroline van HeugtenMaastricht University, the Netherlands.ORCID 0000-0003-4272-7315
Susanne van SantenMaastricht University, the Netherlands.
Annelien A DuitsMaastricht University, the Netherlands.
Janneke HornUniversity of Amsterdam, the Netherlands.
Arjen Jc SlooterUtrecht University, the Netherlands.
Esmée VerwijkUniversity of Amsterdam, the Netherlands.
Johanna Ma Visser-MeilyUtrecht University, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe illness and intensive care treatment pose significant challenges not only for the patients but also for their relatives, known as post-intensive care syndrome in family members (PICS-F). Not much is known about psychosocial outcomes in relatives of former severely ill COVID-19 patients who were hospitalized under pandemic-related challenges. This study aimed to investigate long-term psychosocial outcomes of relatives of formerly hospitalized COVID-19 patients in relation to patient and relative characteristics. Longitudinal data on psychosocial outcomes of relatives of COVID-19 patients, admitted to the general ward or intensive care unit (ICU) in 2020 and enrolled in the multicenter prospective cohort NeNeSCo study, were collected via questionnaires, 9 and 15 months post-hospital discharge of the patient. Outcomes of interest were anxiety, depression, post-traumatic stress symptoms (PTSS), caregiver burden, and quality of life. In general, relatives scored high on PTSS, especially in the ICU group (22.5%). Relatives of ICU patients had higher levels of anxiety and caregiver burden than those of general ward patients. Over time, anxiety decreased while caregiver burden increased in the total group. Factors associated with less favorable outcomes in terms of anxiety, depression, PTSS, and caregiver burden were associated with both relative and patient variables, with relatives' passive coping showing the strongest association across all outcome variables and time. Admission to the ICU increased the level of anxiety in relatives, while patient cognitive complaints were predictive of more severe symptoms in relatives (anxiety, depression, and caregiver burden). In conclusion, nurses providing follow-up care should be aware of the impact of severe COVID-19 on the psychosocial outcomes of relatives, comparable to other severe conditions, and offer guidance, especially to those who will not seek help themselves. Early screening for and psychoeducation on the emotional consequences of severely ill patients can guide nurses in their supportive care.

Indexed as

CaregiversCOVID-19FamilyAdultAgedAnxietyCritical IllnessDepressionFemaleHumansIntensive Care UnitsMaleMiddle AgedProspective StudiesQuality of LifeSARS-CoV-2anxietycaregiver burdenCOVID-19depressionfamily

Identifiers

PMID41181985
PMCPMC12630376

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.