Evidence mapPaperPMID 41183148Full record

ReviewDrug development research2025

Exploring Artificial Intelligence's Potential to Enhance Conventional Anticancer Drug Development.

Sorin-Ștefan Bobolea, Miruna-Ioana Hinoveanu, Andreea Dimitriu, Miruna-Andrada Brașoveanu, Cristian-Nicolae Iliescu, Cristina-Elena Dinu-Pîrvu, Mihaela Violeta Ghica, Valentina Anuța, Lăcrămioara Popa, Răzvan Mihai Prisada

Abstract readReview
In one paragraph

Review in Drug development research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sorin-Ștefan BoboleaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.ORCID https://orcid.org/0009-0006-1497-7682
Miruna-Ioana HinoveanuDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Andreea DimitriuDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Miruna-Andrada BrașoveanuDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Cristian-Nicolae IliescuDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Cristina-Elena Dinu-PîrvuDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Mihaela Violeta GhicaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Valentina AnuțaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Lăcrămioara PopaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Răzvan Mihai PrisadaDepartment of Physical and Colloidal Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Funding

This study was supported by the Institutional Development Fund, CNFIS-FDI-2025-F-0646 and by the Resilience Plan of Romania - Pillar III-C9-I, section I5, Establishment and operationalization of Competence Centers PNRR-III-C9-2022 - I5, managed by the Ministry of Research, Innovation and Digitalization, within the project entitled "Creation, Operational and Development of the National Center of Competence in the field of Cancer", contract no. 760009/30.12.2022, code CF 14/16.11.2022.
6 · The paper itself

Abstract

Cancer affects one in three to four people globally, with over 20 million new cases and 10 million deaths annually, projected to rise to 35 million cases by 2050. Developing effective cancer treatments is crucial, but the drug discovery process is a highly complex and expensive endeavor, with success rates sitting well below 10% for oncologic therapies. More recently, there has been a growing interest in Artificial intelligence (AI) due to its potential to significantly enhance the success rates by processing large data sets, identifying patterns, and making autonomous decisions. The primary aim of this literature review is to examine the potential that state-of-the-art AI tech-nologies have to enhance and complement well-established research methods used in cancer drug development, such as QSAR, interactions prediction, and ADMET prediction, among others. The basic technical aspects of computational technologies are clarified, and key terms commonly asso-ciated with AI are defined. Current applications and case studies from academia and industry are presented to highlight AI's potential to accelerate progress in cancer drug research. Challenges and disadvantages of AI are also acknowledged, and it is discussed that future research should focus on overcoming its limitations to maximize its impact in cancer treatment.

Indexed as

Antineoplastic AgentsArtificial IntelligenceDrug DevelopmentNeoplasmsDrug DiscoveryHumansQuantitative Structure-Activity RelationshipAntineoplastic Agentsartificial intelligence (AI)cancercomputational modelsdeep learning (DL)drug developmentmachine learning (ML)neural networks (NN)

Identifiers

PMID41183148
PMCPMC12582507

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.