ArticleScientific reports2025
Age Stratified Analyses of TyG Index eGDR and Additive Effects on T2DM Outcomes in Prevalence and Mortality.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Associations of Insulin Sensitivity with Risk of All-Cause and Cause-Specific Dementia: A Prospective Cohort Study.Molecular neurobiology · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Although the triglyceride-glucose (TyG) index and estimated glucose disposal rate (eGDR) have emerged as potential biomarkers, the age-specific predictive value of these markers for diabetes progression and long-term outcomes has not been clearly established. We sought to quantify the associations of TyG and eGDR with T2DM incident and all-cause mortality, and further examine whether these associations vary by age. In this cross-sectional and cohort study, a total of 15,457 eligible participants was included, among whom 2,328 had type 2 diabetes mellitus, participants were stratified into two age groups: Young (< 65 years) and old (≥ 65 years) adults. Logistic regression models to evaluate the associations between TyG index, eGDR index and their additive effect with the risk of type 2 diabetes incidence, Kaplan–Meier survival analysis and Cox proportional hazards regression models were utilized to assess the relationships between TyG/eGDR indices and all-cause mortality. TyG index was significantly positively correlated with the risk of type 2 diabetes across different ages. eGDR showed a significant inverse association with type 2 diabetes risk. High TyG and low eGDR were associated with the highest risk of type 2 diabetes. The restricted cubic spline analysis revealed a U-shaped relationship between TyG index and all-cause mortality, a L-shaped curve relationships between eGDR and all-cause mortality in the total and young type 2 diabetes, no significant association was found in the old type 2 diabetes subgroup. The High TyG and low eGDR demonstrated the highest risk of all-cause mortality in the younger type 2 diabetes, but no additive effect was observed in the older type 2 diabetes. TyG and eGDR positively correlated with the risk of type 2 diabetes, and the combination of TyG and eGDR indices improved the identification of the risk and adverse outcome of diabetes, whereas their association with mortality of type 2 diabetes is not significant in the elderly population even in an additive model.
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