Evidence map›Paper›PMID 41184707›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

Adult spinal cord diffuse midline gliomas with piloid features have a better prognosis.

Jingjing Yao, Benqi Zhao, Jianying Chen, Wenying Luo, Hongfang Yin

Abstract read
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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jingjing YaoDepartment of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0002-6128-0259
Benqi ZhaoDepartment of Radiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Jianying ChenDepartment of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Wenying LuoDepartment of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Hongfang YinDepartment of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. yhfa00530@btch.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse midline gliomas of the spinal cord (DMG-SCs) are high-grade, WHO grade 4 gliomas typically associated with a poor prognosis. However, some patients experienced extended survival. We reviewed 43 DMG-SC cases with H3K27M expression and observed that 5 patients with prolonged survival who had Rosenthal fibers and eosinophilic granular bodies in their tumors. These 5 patients (4 males, 1 female, aged 33-64 years, median 53.4) all had thoracic spinal cord tumors. Histologically, the tumors were classified as either low or high-grade gliomas. FAT2 and NF1 were the most common genetic alterations. Notably, these patients had longer preoperative courses and survival times (36 and 25 months, respectively). DNA methylation clustering analysis results show that the five lesions are distributed within the same range. One case is clearly classified as DMG, while others have insufficient calibrated scores. Based on these results, we speculate that DMG-SCs with piloid features may represent a unique subtype with a more favorable prognosis.

Indexed as

GliomaSpinal Cord NeoplasmsAdultDNA MethylationFemaleHumansMaleMiddle AgedPrognosisDiffuse midline gliomasH3 mutationPiloid featuresRosenthal fibersSpinal cord

Identifiers

PMID41184707

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.