ArticleBMC nephrology2025
Cf-PWV but not cr-PWV or cd-PWV is associated with cardiovascular mortality in patients with chronic kidney disease.
Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Pulse Wave Velocity, Mortality and Cardiovascular Disease in Chronic Kidney Disease: A Systematic Review and Meta-Analysis.European journal of clinical investigation · 2026Pooled it
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7 authors.
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Abstract
backgroundIn patients with chronic kidney disease (CKD), it is revealed that carotid-femoral pulse wave velocity (cf-PWV) is related to cardiovascular (CV) mortality, but few studies have investigated carotid-radial PWV (cr-PWV) and carotid-dorsalis pedis PWV (cd-PWV). This study aims at examining the relationship between cf-PWV, cr-PWV, and cd-PWV and CV mortality in CKD patients.
methodsWe enrolled non-dialysis CKD patients with an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m². Baseline arterial stiffness was assessed through office-based measurements of cf-PWV, cr-PWV, and cd-PWV using standardized protocols. Participants were then prospectively followed for all-cause mortality and CV mortality. Cox proportional hazards model and Fine-Gray competing risk model was used to examine the association of cf-PWV, cr-PWV, and cd-PWV with all-cause and CV mortality. Time-dependent receiver operating characteristic (ROC) curve was used to evaluate the predicting performance of cf-PWV on CV mortality.
resultsA total of 233 patients were enrolled. Their average cf-PWV, cr-PWV, and cd-PWV were 12.8 ± 3.6 m/s, 9.9 ± 2.0 m/s, and 9.4 ± 3.7 m/s, respectively. During 9.0(4.0, 12.6) years of follow-up, 144 (61.8%) patients died, of which 76 (52.8%) were due to CV death. After adjustment using multivariate Cox regression analysis, only cf-PWV was an independent risk factor for CV mortality [HR 1.198,95% CI (1.097, 1.308)]. The areas under the curve of cf-PWV for 1-, 3-, 5-, and 10-year of CV death were 0.78, 0.76, 0.70, and 0.75, respectively.
conclusionsIn CKD patients, cf-PWV is associated with CV mortality, and its predictive value remains significant even after 10 years. Cr-PWV and cd-PWV are not associated with either all-cause or CV mortality.
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