Evidence map›Paper›PMID 41185557›Full record

ArticleActa biochimica et biophysica Sinica2025

Combined

Ruifang Ao, Ran Li, Zelin Li, Guicai Wu, Haoran Xu, Xuecong Wang, Jiayi Du, Xiaozheng Zhang, Jun Xie

Abstract read
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ruifang Ao
Ran Li
Zelin Li
Guicai Wu
Haoran Xu
Xuecong Wang
Jiayi Du
Xiaozheng Zhang
Jun Xie

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dolutegravir (DTG) disrupts mouse embryonic development in a dose-dependent manner, culminating in neural-tube defects (NTDs). Using whole embryo culture (WEC), mouse embryos at embryonic day 8.5 (E8.5) are cultured for 24-48 h with 8, 10, or 12 μM DTG. The results reveal that higher DTG concentrations dose-dependently disrupt yolk sac development and markedly increase the frequency of NTDs.

Indexed as

Heterocyclic Compounds, 3-RingNeural Tube DefectsYolk SacAnimalsApoptosisEmbryo, MammalianEmbryonic DevelopmentFemaleMiceOxazinesPiperazinesPregnancyPyridonesHeterocyclic Compounds, 3-RingOxazinesPiperazinesPyridonesDTGNTDoxidative stresswhole embryo cultureyolk sac blood circulation

Identifiers

PMID41185557
PMCPMC13059749

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.