Evidence map›Paper›PMID 41186664›Full record

ArticleGeroScience2026

Transcriptomic analysis of mitohormesis associated with lifespan extension in Caenorhabditis elegans.

Juri Kim, Naibedya Dutta, Gilberto Garcia, Ryo Higuchi-Sanabria

Abstract read
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Juri KimLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Naibedya DuttaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA.
Gilberto GarciaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA. ggarcia1@usc.edu.
Ryo Higuchi-SanabriaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, 90089, USA. ryo.sanabria@usc.edu.ORCID http://orcid.org/0000-0001-8936-5812

Funding

Wormbase SupplementP41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 2000 to 2012
$32.0M
WormBase: a core data resource for C. elegans and other nematodesU41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KERSEY, PAUL, SCHEDL, TIM · 2013 to 2017
$20.5M
WormBase: a core data resource for C. elegans and other nematodesU24HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI TIM SCHEDL, PAUL Warren STERNBERG · 2018 to 2026
$18.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
USC Geroscience Training in the Biology of AgingT32AG052374 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sean P CURRAN · 2016 to 2026
$5.3M
When actin’s not actin like actin: Nuclear actin impacts transcription and agingR01AG079806 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Ryo Higuchi-Sanabria · 2024 to 2026
$1.9M
Larry L. Hillblom Foundation 2022-A-010-SUPNHGRI NIH HHS P41 HG002223NHGRI NIH HHS U24 HG002223NHGRI NIH HHS U41 HG002223NIA NIH HHS R01 AG079806NIA NIH HHS R01AG079806NIA NIH HHS R01AG079806-02S1NIA NIH HHS T32 AG052374NIA NIH HHS T32AG052374NIH HHS P40 OD010440
6 · The paper itself

Abstract

Non-lethal exposure to mitochondrial stress has been shown to have beneficial effects due to activation of signaling pathways, including the mitochondrial unfolded protein response (UPR

Indexed as

Caenorhabditis elegansLongevityMitochondriaTranscriptomeUnfolded Protein ResponseAnimalsGene Expression ProfilingSignal TransductionAgingCaenorhabditis elegansMitohormesisUPRmt

Identifiers

PMID41186664
PMCPMC13574753

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.