Evidence map›Paper›PMID 41186808›Full record

ArticleMolecular biology reports2025

Synergistic neuroprotective effects of Vitexin and Thymol against Okadaic acid-induced neurotoxicity: Computational and In vitro evaluation.

Sakthivel Jafni, Muthuvenugopal Nagakanni, Balakrishnan Indhirakumar, Rajendra Kumar Soundarya Rani, Saravanan Preethi, Vedagiri Hemamalini, Gunasekaran Vanathi, Sundara Dhakshinamurthy Saraswathy, Kasi Pandima Devi

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sakthivel JafniDepartment of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Muthuvenugopal NagakanniDepartment of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Balakrishnan IndhirakumarDepartment of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Rajendra Kumar Soundarya RaniDepartment of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Saravanan PreethiDepartment of Bioinformatics, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India.
Vedagiri HemamaliniDepartment of Bioinformatics, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India.
Gunasekaran VanathiDepartment of Biomedical Science, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India.
Sundara Dhakshinamurthy SaraswathyDepartment of Biomedical Science, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India.
Kasi Pandima DeviDepartment of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India. devikasi@yahoo.com.

Funding

Anusandhan National Research Foundation (ANRF) CRG/2022/000847-G
6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia and inexorable loss of neurons. Despite extensive research, the currently approved drugs offer only limited efficacy which highlights the need for exploring novel synergistic natural compounds capable of mitigating multiple targets of AD. METHODS AND

resultsThis study evaluated the neuroprotective potential of the synergistic combination of Vitexin and Thymol using computational and in vitro model systems in N2a cells. Computational pharmacokinetic screening revealed the blood-brain barrier (BBB) permeability of thymol and 0.55 bioavailability score for Vitexin. Molecular docking studies showed higher binding affinity of Vitexin with JNK and Thymol with COX-1 and CAMK-II and 100 ns molecular dynamics simulation exhibited stable binding with sustained hydrogen bond and hydrophobic interactions. Based on the IC

conclusionThe above findings demonstrate that the combination of Vitexin and Thymol effectively protect the neuronal cells from OA induced cytotoxicity and modulate the hyperactivation of kinases, suggesting its potential in preventing tau hyperphosphorylation in AD conditions.

Indexed as

ApigeninNeuroprotective AgentsThymolAlzheimer DiseaseAnimalsBlood-Brain BarrierCell Line, TumorCell SurvivalDrug SynergismMiceMolecular Docking SimulationMolecular Dynamics SimulationNeuronsApigeninNeuroprotective AgentsThymolvitexinAlzheimer’s diseaseGene expressionNeuroprotectionOkadaic acidSynergismThymolVitexin

Identifiers

PMID41186808

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.