Evidence map›Paper›PMID 41187079›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

eATP sensing by the purinergic receptor PA2072 for allosteric modulation in intracellular c-di-GMP signaling.

Yan Zhang, Xiaojing Gao, Yunjie Xiao, Yajing Duan, Wangxin Xiao, Yangyang Xu, Tingting Yang, Huimin Zhang, Cheng Chen, Shuo Shi and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yan Zhang *Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, People's Republic of China.ORCID 0000-0002-0207-149X
Xiaojing Gao *Department of Biochemistry and Molecular Biology, School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, China.
Yunjie Xiao *Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, People's Republic of China.ORCID 0000-0002-2278-6900
Yajing DuanTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, People's Republic of China.
Wangxin XiaoTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, People's Republic of China.
Yangyang XuTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, People's Republic of China.
Tingting YangTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, People's Republic of China.
Huimin ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, China.
Cheng ChenTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, People's Republic of China.
Shuo ShiState Key Laboratory of Elemento-Organic Chemistry and College of Chemistry, Nankai University, Tianjin 300071, China.
Xun-Cheng SuState Key Laboratory of Elemento-Organic Chemistry and College of Chemistry, Nankai University, Tianjin 300071, China.ORCID 0000-0003-3051-0047
Xinghua JinSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.ORCID 0000-0002-8883-5234
Jiaqing ZhaoResearch Center for Medical Science and Technology, Ningxia Medical University, Yinchuan 750004, China.
Haitao YangShanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.ORCID 0000-0002-1875-3268
Guowei YinScientific Research Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.
Wensu YuanTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, People's Republic of China.
Zefang WangTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, People's Republic of China.ORCID 0000-0002-0852-6483
Weidong HuangDepartment of Biochemistry and Molecular Biology, School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, China.ORCID 0000-0002-4455-0632
Zhi LinTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, Tianjin 300072, People's Republic of China.ORCID 0000-0002-8902-4935

Funding

MOST | National Natural Science Foundation of China (NSFC) 22474086MOST | National Natural Science Foundation of China (NSFC) 81960365
6 · The paper itself

Abstract

Extracellular ATP (eATP) has emerged as a crucial signaling molecule across eukaryotic and prokaryotic domains, modulating diverse cellular functions by activating purinergic receptors to initiate intracellular signaling cascades. However, the structural and molecular mechanisms underlying eATP sensing and signaling by prokaryotic receptors remain largely unknown. Here, we demonstrate that the receptor PA2072 in

Indexed as

Adenosine TriphosphateBacterial ProteinsCyclic GMPPseudomonas aeruginosaReceptors, PurinergicSignal TransductionAdenosine TriphosphatasesAllosteric RegulationHydrolysisProtein MultimerizationAdenosine TriphosphatasesAdenosine TriphosphateBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPReceptors, Purinergicc-di-GMPeATPPA2072purinergic receptorsignaling

Identifiers

PMID41187079
PMCPMC12625894

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.