Evidence map›Paper›PMID 41187619›Full record

ArticleEBioMedicine2025

Soluble urokinase receptor is a kidney-specific vasoconstrictor.

Sebastian Buhl Rasmussen, Rasmus Bo Lindhardt, Georgina Gyarmati, Kirsten Madsen, Claus Bistrup, Lars Lund, Sisse Rye Ostrowski, Changli Wei, Janos Peti-Peterdi, Per Svenningsen and 2 more

Abstract read
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In one paragraph

Article in EBioMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sebastian Buhl RasmussenDepartment of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, 5000, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, 5230, Denmark. Electronic address: sebastian.buhl.rasmussen@rsyd.dk.
Rasmus Bo LindhardtDepartment of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, 5000, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, 5230, Denmark.
Georgina GyarmatiDepartment of Physiology and Neuroscience and Department of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, 90033, USA.
Kirsten MadsenDepartment of Pathology, Odense University Hospital, Odense, 5000, Denmark; Department of Molecular Medicine - Cardiovascular and Renal Research, University of Southern Denmark, Odense, 5230, Denmark.
Claus BistrupDepartment of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, 5230, Denmark; Department of Nephrology, Odense University Hospital, Odense, 5000, Denmark.
Lars LundDepartment of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, 5230, Denmark; Department of Urology, Odense University Hospital, Odense, 5000, Denmark.
Sisse Rye OstrowskiDepartment of Clinical Immunology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, 2100, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Changli WeiDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Janos Peti-PeterdiDepartment of Physiology and Neuroscience and Department of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, 90033, USA.
Per SvenningsenDepartment of Molecular Medicine - Cardiovascular and Renal Research, University of Southern Denmark, Odense, 5230, Denmark.
Jochen ReiserDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA. Electronic address: jreiser@utmb.edu.
Hanne Berg RavnDepartment of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, 5000, Denmark; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, 5230, Denmark.

Funding

suPAR and renal fibrosisR01DK125858 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEI, DAVID CHANGLI · 2020 to 2024
$2.2M
Viral-immune interaction in glomerular kidney diseaseR01DK138055 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI David Changli WEI · 2024 to 2026
$1.8M
NIDDK NIH HHS R01 DK125858NIDDK NIH HHS R01 DK138055
6 · The paper itself

Abstract

backgroundSoluble urokinase plasminogen activator receptor (suPAR) is an innate immune system-derived risk factor for acute and chronic kidney diseases. While suPAR effects on kidney epithelial cells have been reported, its impact on renal vasculature remains unknown.

methodsWe investigated how suPAR affects renal blood flow and glomerular dynamics using a translational approach integrating clinical observations from a propensity-score-matched cardiac surgery cohort, ex vivo porcine kidney perfusion, and intravital multiphoton imaging in mice.

findingsIn the matched clinical cohort, we found a significant inverse correlation between suPAR levels and baseline kidney function, with mean eGFR values 14.5 mL/min/1.73 m

interpretationUnlike many immune mediators, suPAR causes predominantly kidney-specific vasoconstriction, establishing a new class of innate-immune vasoconstrictors with direct implications for causing acute kidney injury in high-risk patients.

fundingSupported by the National Institutes of Health, University of Southern Denmark, Region of Southern Denmark PhD Fund, OUH-RH Joint Research Fund, Danish Kidney Association's Research Fund, Odense University Hospital Research Fund, Goldsmith A. L. Rasmussen Memorial Fund, Dept. of Anaesthesiology-Intensive Care, OUH Research Fund and the MeCiSu Frontline Centre.

Indexed as

KidneyReceptors, Urokinase Plasminogen ActivatorVasoconstrictionAcute Kidney InjuryAgedAnimalsFemaleHumansMaleMiceMiddle AgedRenal CirculationSwineReceptors, Urokinase Plasminogen ActivatorAcute kidney injuryCalcium signallingRenal blood flowsuPARVasoconstriction

Identifiers

PMID41187619
PMCPMC12629921

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.