ArticleRenal failure2025
The association between endothelial activation and stress Index and the development and prognosis of acute kidney injury in elderly patients with critical illness.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Longitudinal Endothelial Activation and Stress Index (EASIX) trajectories and mortality risk in chronic heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Association between endothelial activation and stress index and mortality in critically ill patients with diabetes mellitus: a retrospective cohort study.BMC endocrine disorders · 2026Article
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Authors and funding
9 authors.
Funding
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Abstract
This study investigated the link between the endothelial activation and stress index (EASIX) and acute kidney injury (AKI) development and prognosis in elderly critically ill patients. Using the MIMIC-IV database, we conducted a retrospective cohort study including 12,122 ICU patients aged ≥65 years, of whom 9,124 developed AKI. Patients were divided into three groups based on EASIX scores. We compared the baseline characteristics, mortality rates, and clinical outcomes across groups. Multivariable Cox regression analysis assessed the association between EASIX and AKI development and short-term outcomes, adjusting for confounders. Kaplan-Meier curves and subgroup analyses were performed. Dose-response modeling, threshold effect analysis, and E-value analysis were also conducted. Results showed that patients with the highest EASIX scores had significantly higher mortality rates, with HRs for 28-day mortality of 1.69 (95% CI: 1.47-1.95,
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